7et2
From Proteopedia
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==Human Cytomegalovirus, C12 portal== | ==Human Cytomegalovirus, C12 portal== | ||
| - | <StructureSection load='7et2' size='340' side='right'caption='[[7et2]]' scene=''> | + | <StructureSection load='7et2' size='340' side='right'caption='[[7et2]], [[Resolution|resolution]] 4.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ET2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ET2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7et2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_cytomegalovirus Human cytomegalovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ET2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ET2 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et2 OCA], [https://pdbe.org/7et2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et2 RCSB], [https://www.ebi.ac.uk/pdbsum/7et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et2 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et2 OCA], [https://pdbe.org/7et2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et2 RCSB], [https://www.ebi.ac.uk/pdbsum/7et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/Q6RXD3_HCMV Q6RXD3_HCMV]] Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.[HAMAP-Rule:MF_04012] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry. | ||
| + | |||
| + | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus.,Li Z, Pang J, Dong L, Yu X Nat Commun. 2021 Jul 27;12(1):4538. doi: 10.1038/s41467-021-24820-3. PMID:34315863<ref>PMID:34315863</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7et2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human cytomegalovirus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Li Z]] | + | [[Category: Li, Z]] |
| - | [[Category: Yu X]] | + | [[Category: Yu, X]] |
| + | [[Category: C12 portal]] | ||
| + | [[Category: Partially-enveloped capsid]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:18, 18 August 2021
Human Cytomegalovirus, C12 portal
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