1f2x
From Proteopedia
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'''STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05''' | '''STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2X OCA]. | |
==Reference== | ==Reference== | ||
Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?, Decanniere K, Muyldermans S, Wyns L, J Mol Biol. 2000 Jun 30;300(1):83-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864500 10864500] | Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?, Decanniere K, Muyldermans S, Wyns L, J Mol Biol. 2000 Jun 30;300(1):83-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864500 10864500] | ||
| - | [[Category: Camelus dromedarius]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Decanniere, K.]] | [[Category: Decanniere, K.]] | ||
[[Category: Muyldermans, S.]] | [[Category: Muyldermans, S.]] | ||
[[Category: Wyns, L.]] | [[Category: Wyns, L.]] | ||
| - | [[Category: | + | [[Category: Immunoglobulin fold]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 12:49, 2 May 2008
STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05
Overview
Grafting the antigen-binding loops onto a human antibody scaffold is a widely used technique to humanise murine antibodies. The success of this approach depends largely on the observation that the antigen-binding loops adopt only a limited number of canonical structures. Identification of the correct canonical structure is therefore essential. Algorithms that predict the main-chain conformation of the hypervariable loops using only the amino acid sequence often provide this information. Here, we describe new canonical loop conformations for the hypervariable regions H1 and H2 as found in single-domain antibody fragments of dromedaries or llama. Although the occurrence of these new loop conformations was not predicted by the algorithms used, it seems that they could occur in human or mouse antigen-binding loops. Their discovery indicates that the currently used set of canonical structures is incomplete and that the prediction algorithms should be extended to include these new structures.
About this Structure
Full crystallographic information is available from OCA.
Reference
Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?, Decanniere K, Muyldermans S, Wyns L, J Mol Biol. 2000 Jun 30;300(1):83-91. PMID:10864500 Page seeded by OCA on Fri May 2 15:49:50 2008
