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1m8w
From Proteopedia
(Difference between revisions)
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<StructureSection load='1m8w' size='340' side='right'caption='[[1m8w]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='1m8w' size='340' side='right'caption='[[1m8w]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1m8w]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1m8w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8W FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ib3|1ib3]], [[1ib2|1ib2]], [[1m8x|1m8x]], [[1m8y|1m8y]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ib3|1ib3]], [[1ib2|1ib2]], [[1m8x|1m8x]], [[1m8y|1m8y]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8w OCA], [https://pdbe.org/1m8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8w RCSB], [https://www.ebi.ac.uk/pdbsum/1m8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8w ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 06:54, 18 August 2021
CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA
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