1f3h

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[[Image:1f3h.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3h OCA], [http://www.ebi.ac.uk/pdbsum/1f3h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f3h RCSB]</span>
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'''X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN'''
'''X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN'''
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[[Category: Noel, J P.]]
[[Category: Noel, J P.]]
[[Category: Verdecia, M A.]]
[[Category: Verdecia, M A.]]
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[[Category: alpha-beta,]]
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[[Category: Alpha-beta]]
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[[Category: apoptosis inhibitor survivin]]
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[[Category: Apoptosis inhibitor survivin]]
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[[Category: repeat]]
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[[Category: Repeat]]
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[[Category: thiol protease inhibitor]]
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[[Category: Thiol protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:15:01 2008''
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Revision as of 12:50, 2 May 2008

Image:1f3h.gif

Template:STRUCTURE 1f3h

X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN


Overview

Survivin is a 16.5 kDa protein that is expressed during the G2/M phase of the cell cycle and is hypothesized to inhibit a default apoptotic cascade initiated in mitosis. This inhibitory function is coupled to survivin's localization to the mitotic spindle. To begin to address the structural basis of survivin's function, we report the X-ray crystal structure of a recombinant form of full length survivin to 2.58 A resolution. Survivin consists of two defined domains including an N-terminal Zn2+-binding BIR domain linked to a 65 A amphipathic C-terminal alpha-helix. The crystal structure reveals an extensive dimerization interface along a hydrophobic surface on the BIR domain of each survivin monomer. A basic patch acting as a sulfate/phosphate-binding module, an acidic cluster projecting off the BIR domain, and a solvent-accessible hydrophobic surface residing on the C-terminal amphipathic helix, are suggestive of functional protein-protein interaction surfaces.

About this Structure

1F3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement., Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP, Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:10876248 Page seeded by OCA on Fri May 2 15:50:54 2008

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