1f3j

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[[Image:1f3j.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3j OCA], [http://www.ebi.ac.uk/pdbsum/1f3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f3j RCSB]</span>
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'''HISTOCOMPATIBILITY ANTIGEN I-AG7'''
'''HISTOCOMPATIBILITY ANTIGEN I-AG7'''
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[[Category: Latek, R R.]]
[[Category: Latek, R R.]]
[[Category: Unanue, E R.]]
[[Category: Unanue, E R.]]
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[[Category: histocompatibility antigen]]
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[[Category: Histocompatibility antigen]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: peptide complex]]
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[[Category: Peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:51:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:15:05 2008''
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Revision as of 12:51, 2 May 2008

Image:1f3j.jpg

Template:STRUCTURE 1f3j

HISTOCOMPATIBILITY ANTIGEN I-AG7


Overview

We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other non-autoimmune-associated MHC class II molecules, including novel peptide and heterodimer pairing interactions. The binding groove of I-Ag7 is unusual at both terminal ends, with a potentially solvent-exposed channel at the base of the P1 pocket and a widened entrance to the P9 pocket. Peptide binding studies with variants of the hen egg lysozyme I-Ag7 epitope HEL(11-25) support a comprehensive structure-based I-Ag7 binding motif. Residues critical for T cell recognition were investigated with a panel of HEL(11-25)-restricted clones, which uncovered P1 anchor-dependent structural variations. These results establish a framework for future experiments directed at understanding the role of I-Ag7 in autoimmunity.

About this Structure

1F3J is a Protein complex structure of sequences from Gallus gallus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice., Latek RR, Suri A, Petzold SJ, Nelson CA, Kanagawa O, Unanue ER, Fremont DH, Immunity. 2000 Jun;12(6):699-710. PMID:10894169 Page seeded by OCA on Fri May 2 15:51:05 2008

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