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1f42

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[[Image:1f42.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1f42| PDB=1f42 | SCENE= }}
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|RELATEDENTRY=[[1f45|1F45]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f42 OCA], [http://www.ebi.ac.uk/pdbsum/1f42 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f42 RCSB]</span>
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'''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''
'''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''
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[[Category: Tobin, J F.]]
[[Category: Tobin, J F.]]
[[Category: Yoon, C.]]
[[Category: Yoon, C.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:52:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:15:21 2008''
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Revision as of 12:52, 2 May 2008

Image:1f42.gif

Template:STRUCTURE 1f42

THE P40 DOMAIN OF HUMAN INTERLEUKIN-12


Overview

Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.

About this Structure

1F42 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108 Page seeded by OCA on Fri May 2 15:52:15 2008

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