6w2h
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the Internal UBA Domain of HHR23A== | ==Crystal Structure of the Internal UBA Domain of HHR23A== | ||
| - | <StructureSection load='6w2h' size='340' side='right'caption='[[6w2h]]' scene=''> | + | <StructureSection load='6w2h' size='340' side='right'caption='[[6w2h]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W2H FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6w2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W2H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2h OCA], [https://pdbe.org/6w2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w2h RCSB], [https://www.ebi.ac.uk/pdbsum/6w2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2h ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAD23A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2h OCA], [https://pdbe.org/6w2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w2h RCSB], [https://www.ebi.ac.uk/pdbsum/6w2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/RD23A_HUMAN RD23A_HUMAN]] Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Becht | + | [[Category: Becht, D C]] |
| - | [[Category: Bowler | + | [[Category: Bowler, B E]] |
| - | [[Category: Mou T | + | [[Category: Mou, T C]] |
| - | [[Category: Rothfuss M]] | + | [[Category: Rothfuss, M]] |
| - | [[Category: Sprang | + | [[Category: Sprang, S R]] |
| - | [[Category: Zeng B]] | + | [[Category: Zeng, B]] |
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Helical bundle]] | ||
| + | [[Category: Uba domain]] | ||
| + | [[Category: Ubiquitin associated domain]] | ||
Revision as of 06:26, 25 August 2021
Crystal Structure of the Internal UBA Domain of HHR23A
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