1f48

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[[Image:1f48.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_1f48| PDB=1f48 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f48 OCA], [http://www.ebi.ac.uk/pdbsum/1f48 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f48 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE'''
'''CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE'''
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[[Category: Rosen, B P.]]
[[Category: Rosen, B P.]]
[[Category: Zhou, T.]]
[[Category: Zhou, T.]]
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[[Category: antimonite binding site]]
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[[Category: Antimonite binding site]]
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[[Category: atp binding site]]
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[[Category: Atp binding site]]
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[[Category: p-loop]]
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Revision as of 12:52, 2 May 2008

Image:1f48.jpg

Template:STRUCTURE 1f48

CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE


Overview

Active extrusion is a common mechanism underlying detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. In Escherichia coli, the ArsAB pump provides resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids stimulates ATPase activity. The crystal structure of ArsA reveals that both NBSs and the metal-binding site are located at the interface between two homologous domains. A short stretch of residues connecting the metal-binding site to the NBSs provides a signal transduction pathway that conveys information on metal occupancy to the ATP hydrolysis sites. Based on these structural features, we propose that the metal-binding site is involved directly in the process of vectorial translocation of arsenite or antimonite across the membrane. The relative positions of the NBS and the inferred mechanism of allosteric activation of ArsA provide a useful model for the interaction of the catalytic domains in other transport ATPases.

About this Structure

1F48 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump., Zhou T, Radaev S, Rosen BP, Gatti DL, EMBO J. 2000 Sep 1;19(17):4838-45. PMID:10970874 Page seeded by OCA on Fri May 2 15:52:39 2008

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