1f6b

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[[Image:1f6b.gif|left|200px]]
[[Image:1f6b.gif|left|200px]]
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{{Structure
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|PDB= 1f6b |SIZE=350|CAPTION= <scene name='initialview01'>1f6b</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1f6b", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1f6b| PDB=1f6b | SCENE= }}
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|RELATEDENTRY=[[1hur|1HUR]], [[1rrg|1RRG]], [[1q21|1Q21]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6b OCA], [http://www.ebi.ac.uk/pdbsum/1f6b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f6b RCSB]</span>
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'''CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX'''
'''CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX'''
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[[Category: Huang, M.]]
[[Category: Huang, M.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: mg-containing complex]]
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[[Category: Mg-containing complex]]
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[[Category: n-terminal helix]]
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[[Category: N-terminal helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:57:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:16:47 2008''
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Revision as of 12:57, 2 May 2008

Image:1f6b.gif

Template:STRUCTURE 1f6b

CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX


Overview

The Sar1 GTPase is an essential component of COPII vesicle coats involved in export of cargo from the ER. We report the 1.7-A structure of Sar1 and find that consistent with the sequence divergence of Sar1 from Arf family GTPases, Sar1 is structurally distinct. In particular, we show that the Sar1 NH2 terminus contains two regions: an NH2-terminal extension containing an evolutionary conserved hydrophobic motif that facilitates membrane recruitment and activation by the mammalian Sec12 guanine nucleotide exchange factor, and an alpha1' amphipathic helix that contributes to interaction with the Sec23/24 complex that is responsible for cargo selection during ER export. We propose that the hydrophobic Sar1 NH2-terminal activation/recruitment motif, in conjunction with the alpha1' helix, mediates the initial steps in COPII coat assembly for export from the ER.

About this Structure

1F6B is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export., Huang M, Weissman JT, Beraud-Dufour S, Luan P, Wang C, Chen W, Aridor M, Wilson IA, Balch WE, J Cell Biol. 2001 Dec 10;155(6):937-48. Epub 2001 Dec 10. PMID:11739406 Page seeded by OCA on Fri May 2 15:57:22 2008

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