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1osp

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Revision as of 09:21, 8 September 2021

CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB

Structural highlights

1osp is a 3 chain structure with sequence from Borbu and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

OspA (outer surface protein A) is an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi. The crystal structure of a soluble recombinant form of OspA was solved in a complex with the Fab fragment of mouse monoclonal antibody 184.1 and refined to a resolution of 1.9 A. OspA has a repetitive antiparallel beta topology with an unusual nonglobular region of "freestanding" sheet connecting globular N- and C-terminal domains. Arrays of residues with alternating charges are a predominant feature of the folding pattern in the nonglobular region. The 184.1 epitope overlaps with a well conserved surface in the N-terminal domain, and a hydrophobic cavity buried in a positively charged cleft in the C-terminal domain is a potential binding site for an unknown ligand. An exposed variable region on the C-terminal domain of OspA is predicted to be an important factor in the worldwide effectiveness of OspA-based vaccines.

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab.,Li H, Dunn JJ, Luft BJ, Lawson CL Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:9108020^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Li H, Dunn JJ, Luft BJ, Lawson CL. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:9108020

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1osp"

@@ Line 3: / Line 3: @@
 <StructureSection load='1osp' size='340' side='right'caption='[[1osp]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1osp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Borbu Borbu] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OSP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1osp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Borbu Borbu] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSP FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1osp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osp OCA], [http://pdbe.org/1osp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1osp RCSB], [http://www.ebi.ac.uk/pdbsum/1osp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1osp ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osp OCA], [https://pdbe.org/1osp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osp RCSB], [https://www.ebi.ac.uk/pdbsum/1osp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osp ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

1osp

From Proteopedia

Revision as of 09:21, 8 September 2021

CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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