1pp1

From Proteopedia

(Difference between revisions)

Revision as of 09:32, 8 September 2021

Crystal structure of the Borna Disease Virus Nucleoprotein

Structural highlights

1pp1 is a 1 chain structure with sequence from Bdv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	1n93
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[WNCAP_BDV] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Targets viral NC to the nucleus. Could be involved in the transport of nucleoprotein particles from the nucleus to the cytoplasm. The nuclear export signal is masked by the interaction with the P protein.^[1]

Publication Abstract from PubMed

Borna disease virus (BDV) causes an infection of the central nervous system in a wide range of vertebrates, which can fatally progress to an immune-mediated disease, called Borna disease. BDV is a member of the Mononegavirales, which also includes the highly infectious measles and Ebola viruses. The viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. We present the X-ray structure of the BDV nucleoprotein determined at 1.76 A resolution. The structure reveals a novel fold, organized into two distinct domains, and an assembly into a planar homotetramer. Surface potential calculations strongly support an RNA binding model with the RNA wrapping around the outside of the tetramer, although a positively charged central channel in the tetramer could fit single-stranded RNA in an alternative binding mode. This first structure of an RNA virus nucleoprotein provides a paradigmatic model for RNA packaging and replication of single-stranded RNA viruses.

Crystal structure of the borna disease virus nucleoprotein.,Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R Structure. 2003 Oct;11(10):1219-26. PMID:14527390^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kobayashi T, Kamitani W, Zhang G, Watanabe M, Tomonaga K, Ikuta K. Borna disease virus nucleoprotein requires both nuclear localization and export activities for viral nucleocytoplasmic shuttling. J Virol. 2001 Apr;75(7):3404-12. PMID:11238866 doi:http://dx.doi.org/10.1128/JVI.75.7.3404-3412.2001
↑ Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R. Crystal structure of the borna disease virus nucleoprotein. Structure. 2003 Oct;11(10):1219-26. PMID:14527390

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pp1"

@@ Line 3: / Line 3: @@
 <StructureSection load='1pp1' size='340' side='right'caption='[[1pp1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pp1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdv Bdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PP1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdv Bdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PP1 FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n93|1n93]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n93|1n93]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pp1 OCA], [http://pdbe.org/1pp1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pp1 RCSB], [http://www.ebi.ac.uk/pdbsum/1pp1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pp1 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pp1 OCA], [https://pdbe.org/1pp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pp1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pp1 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/WNCAP_BDV WNCAP_BDV]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Targets viral NC to the nucleus. Could be involved in the transport of nucleoprotein particles from the nucleus to the cytoplasm. The nuclear export signal is masked by the interaction with the P protein.<ref>PMID:11238866</ref>
+[[https://www.uniprot.org/uniprot/WNCAP_BDV WNCAP_BDV]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Targets viral NC to the nucleus. Could be involved in the transport of nucleoprotein particles from the nucleus to the cytoplasm. The nuclear export signal is masked by the interaction with the P protein.<ref>PMID:11238866</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

1pp1

From Proteopedia

Revision as of 09:32, 8 September 2021

Crystal structure of the Borna Disease Virus Nucleoprotein

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox