1r6f

From Proteopedia

(Difference between revisions)

Revision as of 10:08, 15 September 2021

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

Structural highlights

1r6f is a 1 chain structure with sequence from "bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LCRV_YERPE] Possibly involved in calcium regulation of YOP expression, which includes the export process.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The LcrV protein (V-antigen) is a multifunctional virulence factor in Yersinia pestis, the causative agent of plague. LcrV regulates the translocation of cytotoxic effector proteins from the bacterium into the cytosol of mammalian cells via a type III secretion system, possesses antihost activities of its own, and is also an active and passive mediator of resistance to disease. Although a crystal structure of this protein has been actively sought for better understanding of its role in pathogenesis, the wild-type LcrV was found to be recalcitrant to crystallization. We employed a surface entropy reduction mutagenesis strategy to obtain crystals of LcrV that diffract to 2.2 A and determined its structure. The refined model reveals a dumbbell-like molecule with a novel fold that includes an unexpected coiled-coil motif, and provides a detailed three-dimensional roadmap for exploring structure-function relationships in this essential virulence determinant.

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague.,Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS Structure. 2004 Feb;12(2):301-6. PMID:14962390^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS. The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague. Structure. 2004 Feb;12(2):301-6. PMID:14962390 doi:http://dx.doi.org/10.1016/j.str.2004.01.010

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r6f"

@@ Line 3: / Line 3: @@
 <StructureSection load='1r6f' size='340' side='right'caption='[[1r6f]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1r6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1r6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6F FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6f OCA], [http://pdbe.org/1r6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6f RCSB], [http://www.ebi.ac.uk/pdbsum/1r6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6f ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6f OCA], [https://pdbe.org/1r6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6f RCSB], [https://www.ebi.ac.uk/pdbsum/1r6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6f ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/LCRV_YERPE LCRV_YERPE]] Possibly involved in calcium regulation of YOP expression, which includes the export process.
+[[https://www.uniprot.org/uniprot/LCRV_YERPE LCRV_YERPE]] Possibly involved in calcium regulation of YOP expression, which includes the export process.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1r6f

From Proteopedia

Revision as of 10:08, 15 September 2021

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox