1fa0

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[[Image:1fa0.jpg|left|200px]]
[[Image:1fa0.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1fa0 |SIZE=350|CAPTION= <scene name='initialview01'>1fa0</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1fa0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3AD:3&#39;-DEOXYADENOSINE'>3AD</scene>, <scene name='pdbligand=3AT:3&#39;-DEOXYADENOSINE-5&#39;-TRIPHOSPHATE'>3AT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1fa0| PDB=1fa0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fa0 OCA], [http://www.ebi.ac.uk/pdbsum/1fa0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fa0 RCSB]</span>
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}}
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'''STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP'''
'''STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP'''
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[[Category: Moore, C L.]]
[[Category: Moore, C L.]]
[[Category: Zhelkovsky, A M.]]
[[Category: Zhelkovsky, A M.]]
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[[Category: nucleotidyl transferase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: polymerase]]
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[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:05:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:18:58 2008''
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Revision as of 13:05, 2 May 2008

Image:1fa0.jpg

Template:STRUCTURE 1fa0

STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP


Overview

Polyadenylate [poly(A)] polymerase (PAP) catalyzes the addition of a polyadenosine tail to almost all eukaryotic messenger RNAs (mRNAs). The crystal structure of the PAP from Saccharomyces cerevisiae (Pap1) has been solved to 2.6 angstroms, both alone and in complex with 3'-deoxyadenosine triphosphate (3'-dATP). Like other nucleic acid polymerases, Pap1 is composed of three domains that encircle the active site. The arrangement of these domains, however, is quite different from that seen in polymerases that use a template to select and position their incoming nucleotides. The first two domains are functionally analogous to polymerase palm and fingers domains. The third domain is attached to the fingers domain and is known to interact with the single-stranded RNA primer. In the nucleotide complex, two molecules of 3'-dATP are bound to Pap1. One occupies the position of the incoming base, prior to its addition to the mRNA chain. The other is believed to occupy the position of the 3' end of the mRNA primer.

About this Structure

1FA0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP., Bard J, Zhelkovsky AM, Helmling S, Earnest TN, Moore CL, Bohm A, Science. 2000 Aug 25;289(5483):1346-9. PMID:10958780 Page seeded by OCA on Fri May 2 16:05:15 2008

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