6zlv
From Proteopedia
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==MreC== | ==MreC== | ||
| - | <StructureSection load='6zlv' size='340' side='right'caption='[[6zlv]]' scene=''> | + | <StructureSection load='6zlv' size='340' side='right'caption='[[6zlv]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZLV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zlv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZLV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlv OCA], [https://pdbe.org/6zlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zlv RCSB], [https://www.ebi.ac.uk/pdbsum/6zlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlv ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mreC, GNQ20_16665 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zlv OCA], [https://pdbe.org/6zlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zlv RCSB], [https://www.ebi.ac.uk/pdbsum/6zlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zlv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/A0A6A9K3A1_PSEAI A0A6A9K3A1_PSEAI]] Involved in formation and maintenance of cell shape.[PIRNR:PIRNR038471] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell wall biosynthesis enzymes, in a process that may be dependent on MreC self-association. Here, we use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC from Pseudomonas aeruginosa in atomic detail. MreC monomers interact in head-to-tail fashion. Longitudinal and lateral interfaces are essential for oligomerization in vitro, and a phylogenetic analysis of proteobacterial MreC sequences indicates the prevalence of the identified interfaces. Our results are consistent with a model where MreC's ability to alternate between self-association and interaction with the cell wall biosynthesis machinery plays a key role in the regulation of elongasome activity. | ||
| + | |||
| + | Self-association of MreC as a regulatory signal in bacterial cell wall elongation.,Martins A, Contreras-Martel C, Janet-Maitre M, Miyachiro MM, Estrozi LF, Trindade DM, Malospirito CC, Rodrigues-Costa F, Imbert L, Job V, Schoehn G, Attree I, Dessen A Nat Commun. 2021 May 20;12(1):2987. doi: 10.1038/s41467-021-22957-9. PMID:34016967<ref>PMID:34016967</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zlv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Contreras-Martel C]] | + | [[Category: Contreras-Martel, C]] |
| - | [[Category: Estrozi | + | [[Category: Estrozi, L F]] |
| + | [[Category: Bacterial cell wall elongation]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 08:57, 29 September 2021
MreC
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