==DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER==

<StructureSection load='1taf' size='340' side='right'caption='[[1taf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[1taf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TAF FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1taf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1taf OCA], [http://pdbe.org/1taf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1taf RCSB], [http://www.ebi.ac.uk/pdbsum/1taf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1taf ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/TAF9_DROME TAF9_DROME]] TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.<ref>PMID:8221891</ref> [[http://www.uniprot.org/uniprot/TAF6_DROME TAF6_DROME]] TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.<ref>PMID:8262073</ref>

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== Publication Abstract from PubMed ==

A complex of two TFIID TATA box-binding protein-associated factors (TA FIIs) is described at 2.0A resolution. The amino-terminal portions of dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short alpha-helices flanking a long central alpha-helix. Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62 complex exists as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure.

Structural similarity between TAFs and the heterotetrameric core of the histone octamer.,Xie X, Kokubo T, Cohen SL, Mirza UA, Hoffmann A, Chait BT, Roeder RG, Nakatani Y, Burley SK Nature. 1996 Mar 28;380(6572):316-22. PMID:8598927<ref>PMID:8598927</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1taf" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Drome]]

[[Category: Burley, S K]]

[[Category: Transcription initiation]]