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1tcf
From Proteopedia
(Difference between revisions)
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<StructureSection load='1tcf' size='340' side='right'caption='[[1tcf]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1tcf' size='340' side='right'caption='[[1tcf]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1tcf]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1tcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. The August 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcf OCA], [https://pdbe.org/1tcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcf RCSB], [https://www.ebi.ac.uk/pdbsum/1tcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TNNC2_RABIT TNNC2_RABIT]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Role of Troponin C in decreased muscle sensitivity to calcium|Role of Troponin C in decreased muscle sensitivity to calcium]] | ||
*[[Troponin|Troponin]] | *[[Troponin|Troponin]] | ||
__TOC__ | __TOC__ | ||
Revision as of 09:25, 29 September 2021
CRYSTAL STRUCTURE OF CALCIUM-SATURATED RABBIT SKELETAL TROPONIN C
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