1tcf

<table><tr><td colspan='2'>[[1tcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. The August 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCF FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcf OCA], [http://pdbe.org/1tcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcf RCSB], [http://www.ebi.ac.uk/pdbsum/1tcf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcf ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TNNC2_RABIT TNNC2_RABIT]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

*[[Role of Troponin C in decreased muscle sensitivity to calcium|Role of Troponin C in decreased muscle sensitivity to calcium]]