1fb8

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[[Image:1fb8.gif|left|200px]]
[[Image:1fb8.gif|left|200px]]
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{{Structure
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|PDB= 1fb8 |SIZE=350|CAPTION= <scene name='initialview01'>1fb8</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1fb8", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1fb8| PDB=1fb8 | SCENE= }}
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|RELATEDENTRY=[[1fao|1FAO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fb8 OCA], [http://www.ebi.ac.uk/pdbsum/1fb8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fb8 RCSB]</span>
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'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH'''
'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH'''
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[[Category: Skolnik, E Y.]]
[[Category: Skolnik, E Y.]]
[[Category: 3-phosphoinositide]]
[[Category: 3-phosphoinositide]]
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[[Category: adaptor protein]]
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[[Category: Adaptor protein]]
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[[Category: inositol tetrakisphosphate signal transduction protein]]
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[[Category: Inositol tetrakisphosphate signal transduction protein]]
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[[Category: pleckstrin]]
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[[Category: Pleckstrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:07:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:30 2008''
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Revision as of 13:07, 2 May 2008

Image:1fb8.gif

Template:STRUCTURE 1fb8

STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH


Overview

Pleckstrin homology (PH) domains are protein modules of around 120 amino acids found in many proteins involved in cellular signaling. Certain PH domains drive signal-dependent membrane recruitment of their host proteins by binding strongly and specifically to lipid second messengers produced by agonist-stimulated phosphoinositide 3-kinases (PI 3-Ks). We describe X-ray crystal structures of two different PH domains bound to Ins(1,3,4,5)P4, the head group of the major PI 3-K product PtdIns(3,4,5)P3. One of these PH domains (from Grp1) is PtdIns(3,4,5)P3 specific, while the other (from DAPP1/PHISH) binds strongly to both PtdIns(3,4,5)P3 and its 5'-dephosphorylation product, PtdIns(3,4)P2. Comparison of the two structures provides an explanation for the distinct phosphoinositide specificities of the two PH domains and allows us to predict the 3-phosphoinositide selectivity of uncharacterized PH domains.

About this Structure

1FB8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains., Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA, Mol Cell. 2000 Aug;6(2):373-84. PMID:10983984 Page seeded by OCA on Fri May 2 16:07:32 2008

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