1fba

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[[Image:1fba.gif|left|200px]]
[[Image:1fba.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fba |SIZE=350|CAPTION= <scene name='initialview01'>1fba</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1fba", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fba| PDB=1fba | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fba OCA], [http://www.ebi.ac.uk/pdbsum/1fba PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fba RCSB]</span>
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}}
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'''THE CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM DROSOPHILA MELANOGASTER AT 2.5 ANGSTROMS RESOLUTION'''
'''THE CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM DROSOPHILA MELANOGASTER AT 2.5 ANGSTROMS RESOLUTION'''
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[[Category: Hester, G.]]
[[Category: Hester, G.]]
[[Category: Piontek, K.]]
[[Category: Piontek, K.]]
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[[Category: lyase(aldehyde)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:07:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:36 2008''
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Revision as of 13:07, 2 May 2008

Image:1fba.gif

Template:STRUCTURE 1fba

THE CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM DROSOPHILA MELANOGASTER AT 2.5 ANGSTROMS RESOLUTION


Overview

The structure of fructose-1,6-bisphosphate aldolase from Drosophila melanogaster has been determined by X-ray diffraction at 2.5 A resolution. The insect enzyme crystallizes in space group P2(1)2(1)2(1) with lattice replacement with rabbit muscle aldolase as a search model has been employed to solve the structure. To improve the initial phases real space averaging, including phase extension from 4.0 to 2.5 A, has been applied. Refinement of the atomic positions by molecular dynamics resulted in a crystallographic R-factor of 0.214. The tertiary structure resembles in most parts that of the vertebrate aldolase from rabbit muscle. Significant differences were found in surface loops and the N- and C-terminal regions of the protein. Here we present the first aldolase structure where the functionally important C-terminal arm is described completely.

About this Structure

1FBA is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The crystal structure of fructose-1,6-bisphosphate aldolase from Drosophila melanogaster at 2.5 A resolution., Hester G, Brenner-Holzach O, Rossi FA, Struck-Donatz M, Winterhalter KH, Smit JD, Piontek K, FEBS Lett. 1991 Nov 4;292(1-2):237-42. PMID:1959612 Page seeded by OCA on Fri May 2 16:07:45 2008

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