Indole-3-glycerol phosphate synthase
From Proteopedia
(Difference between revisions)
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<StructureSection load='' size='350' side='right' caption='Structure of IGPS complex with IGP (PDB entry [[1a53]])' scene='57/572309/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Structure of IGPS complex with IGP (PDB entry [[1a53]])' scene='57/572309/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Indole-3-glycerol phosphate synthase''' or '''imidazole glycerol phosphate synthase''' (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate ( | + | '''Indole-3-glycerol phosphate synthase''' or '''imidazole glycerol phosphate synthase''' (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CdRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis<ref>PMID:5332729</ref>. |
== Structural highlights == | == Structural highlights == | ||
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**[[3t78]] – MtIGPS + fluoroanthranilate<br /> | **[[3t78]] – MtIGPS + fluoroanthranilate<br /> | ||
**[[1jcm]] – EcIGPS N terminal + CDRP derivative – ''Escherichia coli''<br /> | **[[1jcm]] – EcIGPS N terminal + CDRP derivative – ''Escherichia coli''<br /> | ||
| - | **[[4ewn]] – TmIGPS subunit HISF (mutant) + | + | **[[4ewn]] – TmIGPS subunit HISF (mutant) + rCdRP <br /> |
| + | **[[6y88]] – IGPS + rCdRP – ''Pseudomonas aeruginosa''<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:03, 3 October 2021
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3D structures of IGPS
Updated on 03-October-2021
References
- ↑ Creighton TE, Yanofsky C. Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon. J Biol Chem. 1966 Oct 25;241(20):4616-24. PMID:5332729
- ↑ Hennig M, Darimont BD, Jansonius JN, Kirschner K. The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol. 2002 Jun 7;319(3):757-66. PMID:12054868 doi:http://dx.doi.org/10.1016/S0022-2836(02)00378-9
