Integrin 3D structures

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Revision as of 08:55, 5 October 2021 (edit) Michal Harel (Talk | contribs) ← Previous diff		Revision as of 08:59, 5 October 2021 (edit) (undo) Michal Harel (Talk | contribs) Next diff →
Line 73:		Line 73:
	**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />		**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
-	*IG α-5 (CD49e) β-3 (CD61) ectodomain	+	*IG α-5 (CD49e) + IG β-3 (CD61) ectodomain
	**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />		**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
Line 81:		Line 81:
	**[[1l5g]] - hIG + tripeptide + Mn<br />		**[[1l5g]] - hIG + tripeptide + Mn<br />
-	*IG α-5 β-6	+	*IG α-5 + IG β-6
	**[[4um8]] – hIG headpiece (mutant) + Ni<br />		**[[4um8]] – hIG headpiece (mutant) + Ni<br />
Line 88:		Line 88:
	**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />		**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
	**[[5ffo]] – hIG headpiece + TGF-beta-1<br />		**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
		+
		+	*IG α-6 + IG β-1
		+	**[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br />
		+
		+	*IG α-L
		+
		+	**[[1lfa]] - hIG I domain + Mn <br />
		+	**[[1zon]], [[4ixd]] - hIG I domain <br />
		+	**[[1mqa]] - hIG I domain (mutant) <br />
		+	**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br />
		+	**[[1mq9]] - hIG I domain (mutant) + Mn <br />
		+	**[[1mjn]] - hIG I domain (mutant) + Mg <br />
		+	**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR <br />
		+	**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
		+	**[[2m3e]] – hIG transmembrane domain - NMR<br />
		+
		+	*IG α-L complexes
		+
		+	**[[1cqp]] - hIG I domain + lovastatin + Mg <br />
		+	**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br />
		+	**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
		+	**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
		+	**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
		+	**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
		+	**[[3f78]] - hIG I domain + anesthetic + Mg<br />
		+	**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
		+	**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
		+
		+	*IG α-M
		+
		+	**[[1idn]], [[1na5]] - hIG<br />
		+	**[[1mf7]] - hIG (mutant) <br />
		+	**[[1bho]] - hIG + Mg<br />
		+	**[[1bhq]] - hIG + Cd<br />
		+	**[[1m1u]] - hIG (mutant) + Ca<br />
		+	**[[1n9z]] - hIG (mutant) + Mg<br />
		+	**[[3q3g]], [[3qa3]] – hIG + antibody<br />
		+	**[[4m76]] – hIG + complement C3<br />
		+	**[[2lke]], [[2lkj – hIG cytoplasmic domain – NMR<br />
		+	**[[4xw2]] – hIG + simvastatin<br />
		+	**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
		+
	*IG α-L		*IG α-L
Line 95:		Line 137:
	**[[2m3e]] – hIG transmembrane domain - NMR<br />		**[[2m3e]] – hIG transmembrane domain - NMR<br />
-	*IG α-L β-2	+	*IG α-L + IG β-2
	**[[5e6u]] – hIG headpiece (mutant) + Ni<br />		**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
-	*IG α-V β-3	+	*IG α-V + IG β-3
	**[[6mk0]] – hIG + antagonist<br />		**[[6mk0]] – hIG + antagonist<br />
Line 106:		Line 148:
	**[[6naj]] – hIG + fibronectin<br />		**[[6naj]] – hIG + fibronectin<br />
-	*IG α-V β-8	+	*IG α-V + IG β-8
	**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />		**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
Line 116:		Line 158:
	**[[2luv]] – hIG cytoplasmic domain – NMR<BR />		**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
		+	**[[1n3y]] – hIG domain I (mutant)<br />
-	*IG α-X β-2 (CD18)	+	*IG α-X + IG β-2 (CD18)
	**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />		**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
Line 139:		Line 182:
	**[[2l1c]] – hIG cytoplasmic tail + SHC<br />		**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
	**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />		**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
		+	**[[6bxb]], [[6bxf]] – hIG/hIG α-L <br />
	*IG β-4 (CD104; Gp150)		*IG β-4 (CD104; Gp150)

---

Revision as of 08:59, 5 October 2021

3D structures of integrin

Updated on 05-October-2021 {{#tree:id=OrganizedByTopic|openlevels=0|

• IG CR3

• • 1ido – hIG I domain + Mg – human
    
  • 1jlm - hIG I domain + Mn
    

• IG α-1 (CD49a)

• • 4a0q - hIG I domain (mutant) + Mg
    
  • 2l8s - hIG transmembrane domain – NMR
    
  • 5hgj - hIG VWFA domain
    
  • 2m32 - hIG I domain + collagen peptide
    
  • 1ck4 - rIG I domain – rat
    
  • 1mhp - rIG I domain (mutant) + antibody + Mn
    
  • 2b2x - rIG I domain (mutant) + antibody + Mg
    

• IG α-2 (CD49b)

• • 4bj3, 5e6x, 5e6v - hIG I domain
    
  • 1dzi, 4bj3 - hIG I domain + collagen peptide
    
  • 1v7p - hIG I domain (mutant) + EMS16 + Mn
    
  • 5thp, 6nd8, 6nd9, 6nda, 6ndb, 6ndc, 6ndd, 6nde, 6ndf, 6ndg, 6ndh - hIG residues 170-366 + rhodocetin
    

• IG α-2b

• • 2k1a - hIG transmembrane domain – NMR
    

• IG α-1 + IG β-1 (CD49a-CD49b)

• • 1qc5, 1qcy - hIG I domain (mutant) + Mg
    
  • 1pt6 - hIG I domain + Mg
    

• IG α-2 (CD49b) + IG β

• • 5hj2 - hIG I domain
    
  • 1aox - hIG I domain (mutant) + Mg
    
  • 2k1a - hIG transmembrane domain – NMR
    

• IG α-2b + IG β-3 (CD61)

• • 1kup, 1kuz – hIG proximal domain – NMR
    
  • 1m8o - hIG cytoplasmic domain – NMR
    
  • 4cak – hIG – Cryo-EM
    
  • 2k9j, 2knc, 7kn0 - hIG transmembrane domain – NMR
    
  • 1tye, 3fcu, 3fcs – hIG + Mg
    
  • 3fc3 – hIG (mutant) + Mg
    
  • 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2, 5hdb – hIG headpiece + antibody + Mg
    
  • 4z7q, 4z7o, 4z7n – hIG headpiece + antibody + Mg + tetrapeptide
    
  • 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
    
  • 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
    
  • 6v4p – hIG + antibody – Cryo-EM
    

• IG α-4

• • 4irz - hIG + antibody
    

• IG α-4 (CD49d) + IG β-7

• • 3v4p - hIG headpiece (mutant) + antibody + Mg
    
  • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
    

• IG α-5 (CD49e) + IG β-1 (CD29)

• • 7nxd – hIG + Mg – Cryo-EM
    
  • 7nwl – hIG + fibronectin + laminin – Cryo-EM
    
  • 4wjk - hIG headpiece (mutant) + Mg
    
  • 4wk0, 4wk2, 4wk4 - hIG headpiece (mutant) + peptide + Mg
    
  • 3vi3 - hIG headpiece + antibody + Mg
    
  • 3vi4 - hIG headpiece + antibody + peptide + Mg
    

• IG α-5 (CD49e) + IG β-3 (CD61) ectodomain

• • 3ije, 1m1x, 4g1e, 4g1m, 1u8c – hIG + cation
    
  • 4mmx, 4mmy, 4mmz - hIG + Mn + fibronectin domain 10
    
  • 4o02, 6avu, 6avr, 6avq - hIG + antibody
    
  • 1jv2 - hIG + platelet membrane glycoprotein IIIA + Ca
    
  • 1l5g - hIG + tripeptide + Mn
    

• IG α-5 + IG β-6

• • 4um8 – hIG headpiece (mutant) + Ni
    
  • 5ffg – hIG headpiece + Ca
    
  • 4um9 – hIG headpiece (mutant) + Mg + transforming growth factor β 3
    
  • 5neu, 5net, 5ner, 5nem – hIG headpiece + foot-and-mouth virus – Cryo EM
    
  • 5ffo – hIG headpiece + TGF-beta-1
    

• IG α-6 + IG β-1
  • 7ceb, 7cec – hIG headpiece + laminin + Mg
    

• IG α-L

• • 1lfa - hIG I domain + Mn
    
  • 1zon, 4ixd - hIG I domain
    
  • 1mqa - hIG I domain (mutant)
    
  • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    
  • 1mq9 - hIG I domain (mutant) + Mn
    
  • 1mjn - hIG I domain (mutant) + Mg
    

**2k8o – hIG cytoplasmic domain (mutant) – NMR 

• • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    
  • 2m3e – hIG transmembrane domain - NMR
    

• IG α-L complexes

• • 1cqp - hIG I domain + lovastatin + Mg
    
  • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    
  • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    
  • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    
  • 2o7n, 3m6f - hIG I domain + antagonist
    
  • 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
    
  • 3f78 - hIG I domain + anesthetic + Mg
    
  • 3eoa, 3eob - hIG I domain + antibody
    
  • 3hi6 - hIG I domain (mutant) + antibody + Mn
    

• IG α-M

• • 1idn, 1na5 - hIG
    
  • 1mf7 - hIG (mutant)
    
  • 1bho - hIG + Mg
    
  • 1bhq - hIG + Cd
    
  • 1m1u - hIG (mutant) + Ca
    
  • 1n9z - hIG (mutant) + Mg
    
  • 3q3g, 3qa3 – hIG + antibody
    
  • 4m76 – hIG + complement C3
    
  • 2lke, [[2lkj – hIG cytoplasmic domain – NMR
    
  • 4xw2 – hIG + simvastatin
    
  • 6rhv, 6rhw – hIG + cytolysin
    

• IG α-L

• • 4ixd – hIG I domain
    
  • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    
  • 2m3e – hIG transmembrane domain - NMR
    

• IG α-L + IG β-2

• • 5e6u – hIG headpiece (mutant) + Ni
    

• IG α-V + IG β-3

• • 6mk0 – hIG + antagonist
    
  • 6msl – hIG + cysteine knot protein
    
  • 6msu – hIG + EETI-II
    
  • 6naj – hIG + fibronectin
    

• IG α-V + IG β-8

• • 6djp, 6ujb, 6ujc – hIG + antibody – Cryo EM
    
  • 6om1 – hIG (mutant)
    
  • 6om2 – hIG (mutant) + Protgf-b1 RGD peptide
    
  • 6uja – hIG + Protgf-b1 RGD – Cryo EM
    

• IG α-X

• • 2luv – hIG cytoplasmic domain – NMR
    
  • 1n3y – hIG domain I (mutant)
    

• IG α-X + IG β-2 (CD18)

• • 3k6s, 3k71, 3k72, 5es4 – hIG + Mg
    
  • 4neh, 4nen – hIG (mutant) + Mg
    

• IG β-1D

• • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
    

• IG β-2 (CD18)

• • 2p26, 2p28, 5e6w – hIG phe2 + phe3 domains
    
  • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    
  • 5zaz – hIG transmembrane domain - NMR
    

• IG β-3 (CD61)

• • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    
  • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    
  • 2l91 - hIG transmembrane domain (mutant) – NMR
    
  • 2l1c – hIG cytoplasmic tail + SHC
    
  • 2mtp – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain
    
  • 6bxb, 6bxf – hIG/hIG α-L
    

• IG β-4 (CD104; Gp150)

• • 2f7q, 3f7r, 1qg3, 3f7q, 4wtw, 4wtx - hIG fibronectin type III domain
    
  • 2yrz – hIG fibronectin type III domain – NMR
    
  • 3f7p, 4q58 - hIG fibronectin type III domain + plectin-1
    
  • 6gvl - hIG fibronectin type III domain + dystonin
    
  • 6gvk - hIG fibronectin type III domain (mutant) + dystonin
    
  • 3fq4, 3fso, 3h6a – hIG Calx-β domain
    
  • 6hyf - rIG fibronectin type III domain
    

• IG β-7

• • 2brq, 2jf1 – hIG cytoplasmic tail + filamin rod domain
    

}}