1fbv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1fbv.gif|left|200px]]
[[Image:1fbv.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1fbv |SIZE=350|CAPTION= <scene name='initialview01'>1fbv</scene>, resolution 2.9&Aring;
+
The line below this paragraph, containing "STRUCTURE_1fbv", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1fbv| PDB=1fbv | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fbv OCA], [http://www.ebi.ac.uk/pdbsum/1fbv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fbv RCSB]</span>
+
-
}}
+
'''STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES'''
'''STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES'''
Line 30: Line 27:
[[Category: Wang, P.]]
[[Category: Wang, P.]]
[[Category: Zheng, N.]]
[[Category: Zheng, N.]]
-
[[Category: cbl]]
+
[[Category: Cbl]]
-
[[Category: e2]]
+
[[Category: E2]]
-
[[Category: e3]]
+
[[Category: E3]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: protein degradation,]]
+
[[Category: Protein degradation]]
-
[[Category: tyrosine kinase]]
+
[[Category: Tyrosine kinase]]
-
[[Category: ubch7]]
+
[[Category: Ubch7]]
-
[[Category: ubiquitin]]
+
[[Category: Ubiquitin]]
-
[[Category: ubiquitination]]
+
[[Category: Ubiquitination]]
-
[[Category: zap-70]]
+
[[Category: Zap-70]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:08:45 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:55 2008''
+

Revision as of 13:08, 2 May 2008

Image:1fbv.gif

Template:STRUCTURE 1fbv

STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES


Overview

Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated receptor tyrosine kinases, promotes their ubiquitination by a ubiquitin-conjugating enzyme (E2) and terminates signaling. The crystal structure of c-Cbl bound to a cognate E2 and a kinase peptide shows how the RING domain recruits the E2. A comparison with a HECT family E3-E2 complex indicates that a common E2 motif is recognized by the two E3 families. The structure reveals a rigid coupling between the peptide binding and the E2 binding domains and a conserved surface channel leading from the peptide to the E2 active site, suggesting that RING E3s may function as scaffolds that position the substrate and the E2 optimally for ubiquitin transfer.

About this Structure

1FBV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:10966114 Page seeded by OCA on Fri May 2 16:08:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fbv"
Personal tools