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3m2l
From Proteopedia
(Difference between revisions)
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==Crystal structure of the M113F mutant of alpha-hemolysin== | ==Crystal structure of the M113F mutant of alpha-hemolysin== | ||
| - | <StructureSection load='3m2l' size='340' side='right' caption='[[3m2l]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3m2l' size='340' side='right'caption='[[3m2l]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3m2l]] is a 7 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3m2l]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M2L FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hly, hla ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hly, hla ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m2l OCA], [https://pdbe.org/3m2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m2l RCSB], [https://www.ebi.ac.uk/pdbsum/3m2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m2l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Hemolysin|Hemolysin]] | + | *[[Hemolysin 3D structures|Hemolysin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gouaux, E]] | [[Category: Gouaux, E]] | ||
[[Category: Montoya, M]] | [[Category: Montoya, M]] | ||
Revision as of 05:35, 6 October 2021
Crystal structure of the M113F mutant of alpha-hemolysin
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