6w8x
From Proteopedia
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==Cryo-EM of the S. solfataricus pilus== | ==Cryo-EM of the S. solfataricus pilus== | ||
| - | <StructureSection load='6w8x' size='340' side='right'caption='[[6w8x]]' scene=''> | + | <StructureSection load='6w8x' size='340' side='right'caption='[[6w8x]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W8X OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6w8x]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W8X FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w8x OCA], [https://pdbe.org/6w8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w8x RCSB], [https://www.ebi.ac.uk/pdbsum/6w8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w8x ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 A and 3.4 A resolution, respectively. This triples the number of high resolution archaeal T4P structures, and allows us to pinpoint the evolutionary divergence of bacterial T4P, archaeal T4P and archaeal flagellar filaments. We suggest that extensive glycosylation previously observed in T4P of Sulfolobus islandicus is a response to an acidic environment, as at even higher temperatures in a neutral environment much less glycosylation is present for Pyrobaculum than for Sulfolobus and Saccharolobus pili. Consequently, the Pyrobaculum filaments do not display the remarkable stability of the Sulfolobus filaments in vitro. We identify the Saccharolobus and Pyrobaculum T4P as host receptors recognized by rudivirus SSRV1 and tristromavirus PFV2, respectively. Our results illuminate the evolutionary relationships among bacterial and archaeal T4P filaments and provide insights into archaeal virus-host interactions. | ||
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| + | The structures of two archaeal type IV pili illuminate evolutionary relationships.,Wang F, Baquero DP, Su Z, Beltran LC, Prangishvili D, Krupovic M, Egelman EH Nat Commun. 2020 Jul 9;11(1):3424. doi: 10.1038/s41467-020-17268-4. PMID:32647180<ref>PMID:32647180</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6w8x" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Pilin 3D structures|Pilin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baquero | + | [[Category: Saccharolobus solfataricus]] |
| - | [[Category: Beltran | + | [[Category: Baquero, D P]] |
| - | [[Category: Egelman | + | [[Category: Beltran, L C]] |
| - | [[Category: Krupovic M]] | + | [[Category: Egelman, E H]] |
| - | [[Category: Prangishvili D]] | + | [[Category: Krupovic, M]] |
| - | [[Category: Su Z]] | + | [[Category: Prangishvili, D]] |
| - | [[Category: Wang F]] | + | [[Category: Su, Z]] |
| + | [[Category: Wang, F]] | ||
| + | [[Category: Archaeal pilus]] | ||
| + | [[Category: Helical symmetry]] | ||
| + | [[Category: Protein fibril]] | ||
| + | [[Category: Type iv pilus]] | ||
Revision as of 05:47, 6 October 2021
Cryo-EM of the S. solfataricus pilus
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