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RNA-dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> Due to this protein's importance in the viral life cycle, they are feasible targets for vaccine development.<ref>DOI:10.1038/s41598-018-22328-3</ref> Inhibition of RdRp results in the inhibition of transcription of the viral genome, ultimately resulting in no new production of virions for the virus.
RNA-dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> Due to this protein's importance in the viral life cycle, they are feasible targets for vaccine development.<ref>DOI:10.1038/s41598-018-22328-3</ref> Inhibition of RdRp results in the inhibition of transcription of the viral genome, ultimately resulting in no new production of virions for the virus.
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==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase==
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==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase[https://swissmodel.expasy.org/interactive/7EhwKr/]==
EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic right-hand shape of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The <scene name='89/891377/Fingertips_subdomain_2/4'>fingertips subdomain</scene> is composed of residues 417-439 and 489-563, the <scene name='89/891377/Palm_subdomain_1/5'>palm subdomain</scene> is composed of residues 440-488 and 563-666, and the <scene name='89/891377/Thumb_subdomain/1'>thumb</scene> is made up of residues 667-704.<ref>PMID:26397100</ref>
EBOV has a monomeric RNA-dependent RNA polymerase and as such, shares the characteristic right-hand shape of other monomeric RdRp composed of the fingertips, palm, and thumb subdomains. <ref>PMID:26397100</ref> The <scene name='89/891377/Fingertips_subdomain_2/4'>fingertips subdomain</scene> is composed of residues 417-439 and 489-563, the <scene name='89/891377/Palm_subdomain_1/5'>palm subdomain</scene> is composed of residues 440-488 and 563-666, and the <scene name='89/891377/Thumb_subdomain/1'>thumb</scene> is made up of residues 667-704.<ref>PMID:26397100</ref>

Revision as of 08:48, 12 October 2021

Ebola Virus RNA-Dependent RNA Polymerase

Ebola Virus RNA-Dependent RNA Polymerase

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References

  1. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  2. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  3. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  4. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  5. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  6. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  7. ↑ Malvy D, McElroy AK, de Clerck H, Gunther S, van Griensven J. Ebola virus disease. Lancet. 2019 Mar 2;393(10174):936-948. doi: 10.1016/S0140-6736(18)33132-5. Epub, 2019 Feb 15. PMID:30777297 doi:http://dx.doi.org/10.1016/S0140-6736(18)33132-5
  8. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  9. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  10. ↑ Furuyama W, Marzi A. Ebola Virus: Pathogenesis and Countermeasure Development. Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi:, 10.1146/annurev-virology-092818-015708. PMID:31567063 doi:http://dx.doi.org/10.1146/annurev-virology-092818-015708
  11. ↑ Rojas M, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramirez-Santana C, Ansari AA, Gershwin ME, Anaya JM. Ebola virus disease: An emerging and re-emerging viral threat. J Autoimmun. 2020 Jan;106:102375. doi: 10.1016/j.jaut.2019.102375. Epub 2019 Dec , 3. PMID:31806422 doi:http://dx.doi.org/10.1016/j.jaut.2019.102375
  12. ↑ Rojas M, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramirez-Santana C, Ansari AA, Gershwin ME, Anaya JM. Ebola virus disease: An emerging and re-emerging viral threat. J Autoimmun. 2020 Jan;106:102375. doi: 10.1016/j.jaut.2019.102375. Epub 2019 Dec , 3. PMID:31806422 doi:http://dx.doi.org/10.1016/j.jaut.2019.102375
  13. ↑ Rojas M, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramirez-Santana C, Ansari AA, Gershwin ME, Anaya JM. Ebola virus disease: An emerging and re-emerging viral threat. J Autoimmun. 2020 Jan;106:102375. doi: 10.1016/j.jaut.2019.102375. Epub 2019 Dec , 3. PMID:31806422 doi:http://dx.doi.org/10.1016/j.jaut.2019.102375
  14. ↑ Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Gotte M. Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus. Sci Rep. 2018 Mar 5;8(1):3970. doi: 10.1038/s41598-018-22328-3. PMID:29507309 doi:http://dx.doi.org/10.1038/s41598-018-22328-3
  15. ↑ Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Gotte M. Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus. Sci Rep. 2018 Mar 5;8(1):3970. doi: 10.1038/s41598-018-22328-3. PMID:29507309 doi:http://dx.doi.org/10.1038/s41598-018-22328-3
  16. ↑ Jacome R, Becerra A, Ponce de Leon S, Lazcano A. Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications. PLoS One. 2015 Sep 23;10(9):e0139001. doi: 10.1371/journal.pone.0139001., eCollection 2015. PMID:26397100 doi:http://dx.doi.org/10.1371/journal.pone.0139001
  17. ↑ Jacome R, Becerra A, Ponce de Leon S, Lazcano A. Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications. PLoS One. 2015 Sep 23;10(9):e0139001. doi: 10.1371/journal.pone.0139001., eCollection 2015. PMID:26397100 doi:http://dx.doi.org/10.1371/journal.pone.0139001
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