Kinesin 3D Structures

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Kinesin heavy chain
+
*KIF1A, KIF1B, KIF1C or kinesin-3
-
**[[4ejq]], [[4egx]] - hKIF1A FHA domain - human<br />
+
**[[4ejq]], [[4egx]] - hKIF1A CC1-FHA domain 430-607 - human<br />
**[[1bg2]] – hKIF MD<br />
**[[1bg2]] – hKIF MD<br />
**[[5lt3]], [[5lt4]], [[5lt2]], [[5lt0]], [[5lt1]] – hKIF1 MD (mutant) <br />
**[[5lt3]], [[5lt4]], [[5lt2]], [[5lt0]], [[5lt1]] – hKIF1 MD (mutant) <br />
**[[2g1l]] - hKIF1C FHA domain<br />
**[[2g1l]] - hKIF1C FHA domain<br />
-
**[[5wdh]] – hKIFC1 MD<br />
+
**[[5wdh]] – hKIF1C MD<br />
 +
**[[2rep]] – hKIFC1 MD<br />
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
-
**[[2heh]], [[4ubf]], [[5y05]] – hKIF2C<br />
+
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
-
**[[3b6u]], [[3b6v]] – hKIF3B MD<br />
+
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
-
**[[4a14]] – hKIF7 MD <br />
+
**[[6ojq]] – hKIF1 MD + Tubulin + G2P + GTP – Cryo EM<br />
-
**[[2xt3]] – hKIF7 MD (mutant)<br />
+
**[[4uy0]] – hKIF1 MD + Tubulin + GDP + GTP + ADP – Cryo EM<br />
-
**[[3j2u]] – hKIF10A head domain – Cryo EM<br />
+
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxt]] - hKIF + tubulin 1B, 2B chains + GDP + GTP – Cryo EM <br />
-
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
+
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
-
**[[4bn2]] – hKIF15 MD<br />
+
**[[1mkj]] – hKIF MD+docked FNL<br />
-
**[[2v14]] – hKIF16B<br />
+
**[[6zph]] – hKIF MD + KIF-binding protein – Cryo EM<br />
-
**[[5d3a]] – hKIF21A coiled coil domain 938-1017 <br />
+
**[[2wbe]] – bKIF MD+FNL+Tubulin +AMPPNP – bovine <br />
-
**[[2edu]] – hKIF22 C-terminal – NMR<br />
+
**[[3edl]] – bKIF MD+ Tubulin – EM<br />
-
**[[6nje]] – hKIF22 MD<br />
+
-
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
+
-
**[[6ign]], [[6igv]] – mKIF5B coiled coil domain 444-566 <br />
+
-
**[[3wrd]] – mKIF5C<br />
+
-
**[[5djo]] – mKIF13A CC1-FHA domain <br />
+
-
**[[5djn]] – mKIF13A coiled-coil domain (mutant)<br />
+
-
**[[3kin]], [[2kin]] – rKIF MD - rat<br />
+
-
**[[6a1z]] – rKIF13B<br />
+
-
**[[6a20]] – rKIF13B (mutant)<br />
+
-
**[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
+
-
**[[2y5w]], [[2y65]] - DmKIF MD<br />
+
-
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
+
-
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
+
-
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
+
-
**[[1goj]] – NcKIF MD<br />
+
-
 
+
-
*''Kinesin heavy chain complex with nucleotide''
+
-
 
+
-
**[[2gry]] – hKIF2+ADP<br />
+
-
**[[5wde]] – hKIFC3+ADP<br />
+
-
**[[3nwn]] – hKIF9+ADP<br />
+
-
**[[3gbj]] – hKIF13B MD+ADP <br />
+
-
**[[2cjo]] – hKIF13+inhibitor 30<br />
+
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[2hxh]] - pKIF1A head+ADP<br />
**[[2hxh]] - pKIF1A head+ADP<br />
**[[2hxf]] - pKIF1A head+AMPPNP<br />
**[[2hxf]] - pKIF1A head+AMPPNP<br />
 +
**[[1ia0]] – pKIF1A MD+Tubulin +ATP <br />
 +
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
**[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
**[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
**[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
**[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
 +
**[[4atx]] - rKIF MD+ Tubulin – rat - Cryo EM<br />
 +
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
 +
 +
*KIF2A, KIF2B, KIF2C or kinesin-13
 +
 +
**[[2heh]], [[4ubf]], [[5y05]] – hKIF2C<br />
 +
**[[2gry]] – hKIF2+ADP<br />
 +
**[[5mio]] – hKIF2C MD + Tubulin <br />
**[[1v8j]], [[5xja]], [[5xjb]] – mKIF2C MD+Mg-ADP<br />
**[[1v8j]], [[5xja]], [[5xjb]] – mKIF2C MD+Mg-ADP<br />
**[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
**[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
**[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
**[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
**[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br />
**[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br />
-
**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
+
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
-
**[[3x2t]] – mKIF5C + ADP<br />
+
-
**[[5gsy]] – mKIF19A MD + GDP<br />
+
-
**[[5gsz]] – mKIF19A MD + ADP<br />
+
 +
*KIF3A, KIF3B, KIF3C or kinesin-2
-
*''Kinesin heavy chain complex with protein''
+
**[[3b6u]], [[3b6v]] – hKIF3B MD<br />
 +
**[[2h58]], [[5wde]] – hKIFC3+ADP<br />
-
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
+
*KIF4A, KIF4B or kinesin-4
-
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
+
 
-
**[[6ojq]] – hKIF1 MD + Tubulin + G2P + GTP – Cryo EM<br />
+
**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
-
**[[4uy0]] – hKIF1 MD + Tubulin + GDP + GTP + ADP – Cryo EM<br />
+
 
-
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
+
*KIF5B, KIF5C or kinesin-1
-
**[[1mkj]] – hKIF MD+docked FNL<br />
+
 
-
**[[5mio]] – hKIF2C MD + Tubulin <br />
+
**[[6ign]], [[6igv]] – mKIF5B coiled coil domain 444-566 <br />
-
**[[3fm8]] – hKIF13B FHA domain + centaurin-alpha-1<br />
+
**[[3wrd]] – mKIF5C<br />
-
**[[3md8]] – hKIF13B FHA domain + centaurin-alpha-1 + IP4<br />
+
**[[3x2t]] – mKIF5C + ADP<br />
-
**[[3vhx]] – hKIF23 794-911 + ADP-ribosylation factor 6 <br />
+
-
**[[2wbe]] – bKIF MD+FNL+Tubulin +AMPPNP – bovine <br />
+
-
**[[3edl]] – bKIF MD+ Tubulin – EM<br />
+
-
**[[1ia0]] – pKIF1A MD+Tubulin +ATP <br />
+
-
**[[4atx]] - rKIF MD+ Tubulin – Cryo EM<br />
+
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br />
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br />
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin<br />
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin<br />
-
**[[5nd3]] – mKIF20A MD + tubulin <br />
 
-
**[[5nd2]], [[5nd4]] – mKIF20A MD + tubulin + ADP <br />
 
-
**[[5nd7]] – mKIF20A MD + tubulin + AMPPNP <br />
 
-
**[[5lef]] – mKIF20A residues 603-665 + RAB-6 <br />
 
-
**[[1n6m]] – DmKIF MD+FNL<br />
 
-
*Kinesin light chain (KLC)
+
*KIF7 or kinesin-4
-
**[[5oj8]] – hKLC1 TPR domain <br />
+
**[[4a14]] – hKIF7 MD <br />
-
**[[3edt]] – hKLC2<br />
+
**[[2xt3]] – hKIF7 MD (mutant)<br />
-
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
+
-
**[[6f9i]] – hKLC2 + clcytenin peptide <br />
+
-
**[[6fv0]] – mKLC1 TPR domain + nanobody<br />
+
-
**[[5ojf]] – mKLC2 TPR domain <br />
+
-
**[[3zfw]], [[5fjy]], [[6ejn]] - mKLC2 TPR domain + peptide<br />
+
-
*Kinesin-3 motor domain
+
*KIF9 or kinesin-9
-
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxt]] - KIF + tubulin 1B, 2B chains + GDP + GTP – bovine – Cryo EM <br />
+
**[[3nwn]] – hKIF9+ADP<br />
-
**[[5zbs]] – rKIF13B (mutant)<br />
+
-
**[[5zbr]] – rKIF13B + AMPPNP<br />
+
-
**[[5b64]] – mKIF13B + MAGUK<br />
+
-
*Kinesin-5 motor domain
+
*KIF10A or kinesin-6
-
**[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
+
**[[3j2u]] – hKIF10A head domain – Cryo EM<br />
-
**[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
+
**[[6b0c]] – DmKlp10A + tubulin + GTP + GDP + ANP + Mg – Cryo EM<br />
 +
 
 +
*KIF11 or kinesin-5
 +
 
 +
[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
 +
[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
**[[3wpn]] - hKIF11 +inhibitor <br />
**[[3wpn]] - hKIF11 +inhibitor <br />
-
**[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
+
[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
-
**[[4bxn]], [[4as7]] - hKIF11+inhibitor +ADP + Cd<br />
+
[[4bxn]], [[4as7]] - hKIF11+inhibitor +ADP + Cd<br />
-
**[[3l9h]] - hKIF11+inhibitor +ADP <br />
+
[[3l9h]] - hKIF11+inhibitor +ADP <br />
**[[4zhi]] – hKIF11 MD +ADP<br />
**[[4zhi]] – hKIF11 MD +ADP<br />
-
**[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
+
[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
-
**[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
+
[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
-
**[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
+
[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
-
**[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
+
[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
**[[4zca]] - hKIF11 (mutant) +ADP+Mg<br />
**[[4zca]] - hKIF11 (mutant) +ADP+Mg<br />
-
**[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
+
[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
-
**[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
+
**[[6zpi]] – hKIF11 MD + tubulin + GDP + GTP + Mg – Cryo EM<br />
-
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
+
[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
-
**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
+
[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
-
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br />
+
**[[6ta3]], [[6tiw]] – hKIF11 MD (mutant) + tubulin + G2P + quinolin derivative + Mg – Cryo EM<br />
-
**[[5mm4]], [[5mm7]] – KIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br />
+
**[[6ta4]] – hKIF11 MD + tubulin + G2P + ANP + Mg – Cryo EM<br />
 +
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF MD + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br />
 +
**[[5mm4]], [[5mm7]] – UmKIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br />
-
*Kinesin-6
+
*KIF13A, KIF13B or kinesin-3
-
**[[5x3e]] - KLP MD - ''Caenorhabditis elegans''<br />
+
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
 +
**[[3gbj]] – hKIF13B MD+ADP <br />
 +
**[[2cjo]] – hKIF13+inhibitor 30<br />
 +
**[[3fm8]] – hKIF13B FHA domain + centaurin-alpha-1<br />
 +
**[[3md8]] – hKIF13B FHA domain + centaurin-alpha-1 + IP4<br />
 +
**[[5djo]] – mKIF13A CC1-FHA domain <br />
 +
**[[5djn]] – mKIF13A coiled-coil domain (mutant)<br />
 +
**[[5b64]] – mKIF13B + MAGUK<br />
 +
**[[3kin]], [[2kin]] – rKIF MD <br />
 +
**[[6a1z]] – rKIF13B<br />
 +
**[[6a20]] – rKIF13B (mutant)<br />
 +
**[[5zbs]] – rKIF13B (mutant)<br />
 +
**[[5zbr]] – rKIF13B + AMPPNP<br />
-
*Kinesin-8
+
*KIF14 or kinesin-3
 +
 
 +
**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - yKar3 MD (mutant) – yeast<br />
 +
**[[4etp]] - yKar3 MD (mutant) + VIK1<br />
 +
 
 +
*KIF15 or kinesin-12
 +
 
 +
**[[4bn2]] – hKIF15 MD<br />
 +
 
 +
*KIF16B or kinesin-3
 +
 
 +
**[[2v14]] – hKIF16B<br />
 +
 
 +
*KIF18A, KIF18B or kinesin-8
**[[3lre]] - hKIF18A MD <br />
**[[3lre]] - hKIF18A MD <br />
Line 134: Line 135:
**[[5ogc]] - hKIF18A MD + tubulin + GTP + GDP + taxol<br />
**[[5ogc]] - hKIF18A MD + tubulin + GTP + GDP + taxol<br />
-
*Kinesin-14
+
*KIF19A or kinesin-8
-
**[[3l1c]] – DmNCD (mutant)
+
**[[5gsy]] – mKIF19A MD + GDP<br />
-
**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - yKar3 MD (mutant) - yeast<br />
+
**[[5gsz]] – mKIF19A MD + ADP<br />
-
**[[4etp]] - yKar3 MD (mutant) + VIK1<br />
+
 +
*KIF20A, KIF20B or kinesin-6
 +
 +
**[[5nd3]] – mKIF20A MD + tubulin <br />
 +
**[[5nd2]], [[5nd4]] – mKIF20A MD + tubulin + ADP <br />
 +
**[[5nd7]] – mKIF20A MD + tubulin + AMPPNP <br />
 +
**[[5lef]] – mKIF20A residues 603-665 + RAB-6 <br />
 +
**[[5x3e]] - KLP MD - Caenorhabditis elegans<br />
 +
 +
*KIF21A, KIF21B or kinesin-4
 +
 +
**[[5d3a]] – hKIF21A coiled coil domain 938-1017 <br />
 +
 +
*KIF22 or kinesin-10
 +
 +
**[[2edu]] – hKIF22 C-terminal – NMR<br />
 +
**[[3bfn]] – hKIF22 MD<br />
 +
**[[6nje]] – hKIF22 MD +ADP<br />
 +
 +
*KIF23 or kinesin-6
 +
 +
**[[3vhx]] – hKIF23 794-911 + ADP-ribosylation factor 6 <br />
 +
 +
 +
**[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
 +
**[[2y5w]], [[2y65]] - DmKIF MD<br />
 +
**[[4pxt]], [[4pxu]] – DmKIF MD (mutant)<br />
 +
**[[1n6m]] – DmKIF MD+FNL<br />
 +
**[[3l1c]] – DmNCD (mutant)<br />
 +
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
 +
**[[1goj]] – NcKIF MD<br />
 +
 +
*Kinesin light chain (KLC)
 +
 +
**[[5oj8]] – hKLC1 TPR domain <br />
 +
3edt – hKLC2
 +
3ceq, 3nf1 – hKLC2 TPR domain
 +
**[[6f9i]] – hKLC2 + clcytenin peptide <br />
 +
**[[6fv0]] – mKLC1 TPR domain + nanobody<br />
 +
**[[5ojf]] – mKLC2 TPR domain <br />
 +
**[[3zfw]], [[5fjy]], [[6ejn]] - mKLC2 TPR domain + peptide<br />
*KCBP
*KCBP
-
**[[3h4s]] – KCBP+ADP+Mg – ''Arabidopsis thaliana''<br />
+
**[[3h4s]] – KCBP+ADP+Mg – Arabidopsis thaliana<br />
*NOD
*NOD
-
**[[3dc4]] – DmNOD catalytic core domain+ADP<br />
+
**[[3dc4]] – DmNOD catalytic core domain+ADP + Mg<br />
-
**[[3dcb]] - DmNOD catalytic core domain+AMPPNP<br />
+
**[[3dcb]] - DmNOD catalytic core domain+AMPPNP + Mg<br />
-
**[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
+
**[[3dco]] - DmNOD catalytic core domain+ cTubulin + ADP + GDP + GTP + Mg<br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:16, 13 October 2021

3D Structures of Kinesin

Updated on 13-October-2021

4b7b - hKIF11 (mutant) + ADP + Co + Cd
3ken, 2wog, 2x2r, 2xae, 4bbg - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg
2uyi, 2uym, 2gm1, 2pg2, 2fme, 2x7d, 2x7c, 2ieh, 3cjo, 2g1q, 2fl2, 2fl6, 1yrs, 2q2y, 2fky, 2q2z, 3k3b, 2x7e, 4a50, 4a51, 3zcw - hKIF11+inhibitor +ADP + Mg
4bxn, 4as7 - hKIF11+inhibitor +ADP + Cd
3l9h - hKIF11+inhibitor +ADP
1x88, 1q0b - hKIF11 +Mg + ADP+monastrol
4ap0, 4a5y - hKIF11 +MgADP + ispinesib + Mg
3hqd - hKIF11 +AMPPNP+Mg
1ii6, 4a1z, 4a28 - hKIF11 +ADP+Mg
3k5e - hKIF11 +ADP+enastrol + Mg
4aqv, 4aqw – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM
4ck5, 4ck6, 4ck7 – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM


3edt – hKLC2 3ceq, 3nf1 – hKLC2 TPR domain

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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