1fdl

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[[Image:1fdl.gif|left|200px]]
[[Image:1fdl.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fdl |SIZE=350|CAPTION= <scene name='initialview01'>1fdl</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1fdl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1fdl| PDB=1fdl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fdl OCA], [http://www.ebi.ac.uk/pdbsum/1fdl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fdl RCSB]</span>
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}}
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'''CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5-ANGSTROMS RESOLUTION'''
'''CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5-ANGSTROMS RESOLUTION'''
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[[Category: Fischmann, T O.]]
[[Category: Fischmann, T O.]]
[[Category: Poljak, R J.]]
[[Category: Poljak, R J.]]
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[[Category: complex (antibody-antigen)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:12:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:20:51 2008''
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Revision as of 13:12, 2 May 2008

Image:1fdl.gif

Template:STRUCTURE 1fdl

CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5-ANGSTROMS RESOLUTION


Overview

The three-dimensional crystal structure of the complex between the Fab from the monoclonal anti-lysozyme antibody D1.3 and the antigen, hen egg white lysozyme, has been refined by crystallographic techniques using x-ray intensity data to 2.5-A resolution. The antibody contacts the antigen with residues from all its complementarity determining regions. Antigen residues 18-27 and 117-125 form a discontinuous antigenic determinant making hydrogen bonds and van der Waals interactions with the antibody. Water molecules at or near the antigen-antibody interface mediate some contacts between antigen and antibody. The fine specificity of antibody D1.3, which does not bind (K alpha less than 10(5) M-1) avian lysozymes where Gln121 in the amino acid sequence is occupied by His, can be explained on the basis of the refined model.

About this Structure

1FDL is a Protein complex structure of sequences from Gallus gallus and Mus musculus. The following page contains interesting information on the relation of 1FDL with [Antibodies]. Full crystallographic information is available from OCA.

Reference

Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution., Fischmann TO, Bentley GA, Bhat TN, Boulot G, Mariuzza RA, Phillips SE, Tello D, Poljak RJ, J Biol Chem. 1991 Jul 15;266(20):12915-20. PMID:1712773 Page seeded by OCA on Fri May 2 16:12:19 2008

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