3ih7
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3ih7' size='340' side='right'caption='[[3ih7]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='3ih7' size='340' side='right'caption='[[3ih7]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ih7]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ih7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IH7 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yqk|1yqk]], [[2nol|2nol]], [[1yqr|1yqr]], [[1ebm|1ebm]], [[1n3c|1n3c]], [[2i5w|2i5w]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yqk|1yqk]], [[2nol|2nol]], [[1yqr|1yqr]], [[1ebm|1ebm]], [[1n3c|1n3c]], [[2i5w|2i5w]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMH, MUTM, OGG1, OGH1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMH, MUTM, OGG1, OGH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ih7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ih7 OCA], [https://pdbe.org/3ih7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ih7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ih7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ih7 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
==See Also== | ==See Also== | ||
Revision as of 12:10, 13 October 2021
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
| |||||||||||
