This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3kbx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human macrophage inflammatory protein-1 alpha L3M_V63M== | ==Human macrophage inflammatory protein-1 alpha L3M_V63M== | ||
| - | <StructureSection load='3kbx' size='340' side='right' caption='[[3kbx]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='3kbx' size='340' side='right'caption='[[3kbx]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3kbx]] is a 5 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3kbx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL3, G0S19-1, MIP1A, SCYA3 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL3, G0S19-1, MIP1A, SCYA3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbx OCA], [https://pdbe.org/3kbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbx RCSB], [https://www.ebi.ac.uk/pdbsum/3kbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CCL3_HUMAN CCL3_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).<ref>PMID:8525373</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 16: | Line 16: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Guo, Q]] | [[Category: Guo, Q]] | ||
[[Category: Ren, M]] | [[Category: Ren, M]] | ||
Revision as of 12:23, 13 October 2021
Human macrophage inflammatory protein-1 alpha L3M_V63M
| |||||||||||
Categories: Human | Large Structures | Guo, Q | Ren, M | Tang, W J | Chemokine | Chemotaxis | Cytokine | Inflammatory response | Secreted
