6udm
From Proteopedia
(Difference between revisions)
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==Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726== | ==Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726== | ||
| - | <StructureSection load='6udm' size='340' side='right'caption='[[6udm]]' scene=''> | + | <StructureSection load='6udm' size='340' side='right'caption='[[6udm]], [[Resolution|resolution]] 3.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UDM OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6udm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UDM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=Q4P:[(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone'>Q4P</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP1A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6udm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6udm OCA], [https://pdbe.org/6udm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6udm RCSB], [https://www.ebi.ac.uk/pdbsum/6udm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6udm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CP1A1_HUMAN CP1A1_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bart | + | [[Category: Bart, A G]] |
| - | [[Category: Scott | + | [[Category: Scott, E E]] |
| + | [[Category: Cyp1a1]] | ||
| + | [[Category: Duocarmycin]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: P450]] | ||
Revision as of 12:44, 13 October 2021
Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726
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Categories: Human | Large Structures | Bart, A G | Scott, E E | Cyp1a1 | Duocarmycin | Oxidoreductase | P450
