1iiu

From Proteopedia

(Difference between revisions)

Revision as of 13:14, 13 October 2021

Chicken plasma retinol-binding protein (RBP)

Structural highlights

1iiu is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1aqb, 1hbp, 1hbq, 1rbp
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RET4_CHICK] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.

Structure of chicken plasma retinol-binding protein.,Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R Biochim Biophys Acta. 2001 Nov 26;1550(1):64-9. PMID:11738088^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R. Structure of chicken plasma retinol-binding protein. Biochim Biophys Acta. 2001 Nov 26;1550(1):64-9. PMID:11738088

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iiu"

@@ Line 3: / Line 3: @@
 <StructureSection load='1iiu' size='340' side='right'caption='[[1iiu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1iiu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1iiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aqb|1aqb]], [[1hbp|1hbp]], [[1hbq|1hbq]], [[1rbp|1rbp]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aqb|1aqb]], [[1hbp|1hbp]], [[1hbq|1hbq]], [[1rbp|1rbp]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iiu OCA], [http://pdbe.org/1iiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iiu RCSB], [http://www.ebi.ac.uk/pdbsum/1iiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iiu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iiu OCA], [https://pdbe.org/1iiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iiu RCSB], [https://www.ebi.ac.uk/pdbsum/1iiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iiu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RET4_CHICK RET4_CHICK]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli (By similarity).
+[[https://www.uniprot.org/uniprot/RET4_CHICK RET4_CHICK]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1iiu

From Proteopedia

Revision as of 13:14, 13 October 2021

Chicken plasma retinol-binding protein (RBP)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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