==1.9 A RESOLUTION REFINED STRUCTURE OF TBP RECOGNIZING THE MINOR GROOVE OF TATAAAAG==

<StructureSection load='1vto' size='340' side='right'caption='[[1vto]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[1vto]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VTO FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vto OCA], [http://pdbe.org/1vto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vto RCSB], [http://www.ebi.ac.uk/pdbsum/1vto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vto ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH]] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

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== Publication Abstract from PubMed ==

The three-dimensional structure of a TATA box-binding protein (TBP) from Arabidopsis thaliana complexed with a fourteen base pair oligonucleotide bearing the Adenovirus major late promoter TATA element has been refined at 1.9 A resolution, giving a final crystallographic R-factor of 19.4%. Binding of the monomeric, saddle-shaped alpha/beta protein induces an unprecedented conformational change in the DNA. A detailed structural and functional analysis of this unusual protein-DNA complex is presented, with particular emphasis on the mechanisms of DNA deformation, TATA element recognition, and preinitiation complex assembly.

1.9 A resolution refined structure of TBP recognizing the minor groove of TATAAAAG.,Kim JL, Burley SK Nat Struct Biol. 1994 Sep;1(9):638-53. PMID:7634103<ref>PMID:7634103</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1vto" style="background-color:#fffaf0;"></div>

==See Also==

*[[TATA-Binding Protein|TATA-Binding Protein]]

== References ==

<references/>

[[Category: Arabidopsis thaliana]]

[[Category: Burley, S K]]

[[Category: Protein-dna complex]]

[[Category: Transcription-dna complex]]