1w0t
From Proteopedia
(Difference between revisions)
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<StructureSection load='1w0t' size='340' side='right'caption='[[1w0t]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1w0t' size='340' side='right'caption='[[1w0t]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1w0t]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1w0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0T FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ba5|1ba5]], [[1h6o|1h6o]], [[1ity|1ity]], [[1iv6|1iv6]], [[1w0u|1w0u]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ba5|1ba5]], [[1h6o|1h6o]], [[1ity|1ity]], [[1iv6|1iv6]], [[1w0u|1w0u]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0t OCA], [https://pdbe.org/1w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0t RCSB], [https://www.ebi.ac.uk/pdbsum/1w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 13:29, 13 October 2021
hTRF1 DNA-binding domain in complex with telomeric DNA.
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