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2bbi

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Revision as of 13:37, 13 October 2021

THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION

Structural highlights

2bbi is a 1 chain structure with sequence from Glycine hispida. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1bbi
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IBB1_SOYBN] Inhibitor of trypsin and of chymotrypsin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution has been determined by two-dimensional 1H nuclear magnetic resonance spectroscopy and dynamical simulated annealing using the program XPLOR. The structure was defined by 907 NOEs involving intra- and interresidue contacts which served as distance constraints for a protocol of dynamical simulated annealing. In addition, 48 phi angle constraints involving non-proline amino acids, 29 chi angle constraints, six omega angle constraints for the X-Pro peptide bond, and 35 stereoassignments for prochiral centers were incorporated during the course of the calculation. The protein is characterized by two distinct binding domains for serine protease. Each domain is comprised of a beta-hairpin (antiparallel beta-sheet and a cis-proline-containing type VIb reverse turn) with a short segment making a third strand of antiparallel beta-sheet. The structure determination and refinement are described, and the structure is compared to other structures of Bowman-Birk inhibitors as well as other families of serine protease inhibitors.

Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution.,Werner MH, Wemmer DE Biochemistry. 1992 Feb 4;31(4):999-1010. PMID:1734975^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Werner MH, Wemmer DE. Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution. Biochemistry. 1992 Feb 4;31(4):999-1010. PMID:1734975

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bbi"

Categories: Glycine hispida | Large Structures | Wemmer, D E | Werner, M H | Serine protease inhibitor

@@ Line 3: / Line 3: @@
 <StructureSection load='2bbi' size='340' side='right'caption='[[2bbi]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bbi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycine_hispida Glycine hispida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_hispida Glycine hispida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBI FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bbi|1bbi]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bbi|1bbi]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbi OCA], [http://pdbe.org/2bbi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbi RCSB], [http://www.ebi.ac.uk/pdbsum/2bbi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbi ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbi OCA], [https://pdbe.org/2bbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbi RCSB], [https://www.ebi.ac.uk/pdbsum/2bbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbi ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/IBB1_SOYBN IBB1_SOYBN]] Inhibitor of trypsin and of chymotrypsin.
+[[https://www.uniprot.org/uniprot/IBB1_SOYBN IBB1_SOYBN]] Inhibitor of trypsin and of chymotrypsin.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 30: @@
 ==See Also==
-*[[Trypsin inhibitor|Trypsin inhibitor]]
+*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
 == References ==
 <references/>

2bbi

From Proteopedia

Revision as of 13:37, 13 October 2021

THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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