Activators
From Proteopedia
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<StructureSection load='' scene='Phosphofructokinase_(PFK)/4pfk_biol/3' size='350' | <StructureSection load='' scene='Phosphofructokinase_(PFK)/4pfk_biol/3' size='350' | ||
caption='PFK: R-state Biological tetramer complex with fructose-6-phosphate, ADP and Mg+2 ion; generated from [[4pfk]] by QPS' > | caption='PFK: R-state Biological tetramer complex with fructose-6-phosphate, ADP and Mg+2 ion; generated from [[4pfk]] by QPS' > | ||
| - | + | Enzyme activators are molecules that bind to enzymes and increase their activity. | |
| + | *An example of an enzyme activator working in this way is fructose 2,6-bisphosphate, which activates [[Phosphofructokinase (PFK)|phosphofructokinase 1]] and increases the rate of [[Glycolysis Enzymes|glycolysis]] in response to the hormone [[glucagon]]. | ||
| + | *[[Hexokinase]]-I (HK-I) is an enzyme activator because it draws glucose into the [[Glycolysis Enzymes|glycolysis]] pathway. Its function is to phosphorylate glucose releasing glucose-6-phosphate (G6P) as the product. HK-I not only signals the activation of glucose into glycolysis but also maintains a low glucose concentration to facilitate glucose diffusion into the cell. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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