1fgb
From Proteopedia
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'''TOXIN''' | '''TOXIN''' | ||
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[[Category: Westbrook, E.]] | [[Category: Westbrook, E.]] | ||
[[Category: Zhang, R G.]] | [[Category: Zhang, R G.]] | ||
| - | [[Category: | + | [[Category: Adp-ribosylation]] |
| - | [[Category: | + | [[Category: Cholera toxin]] |
| - | [[Category: | + | [[Category: Choleragenoid]] |
| - | [[Category: | + | [[Category: Enterotoxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:17:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:17, 2 May 2008
TOXIN
Overview
Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio cholera, induces a profuse secretory diarrhea in susceptible hosts. Choleragenoid, the B subunit pentamer of cholera toxin, directs the enzymatic A subunit to its target by binding the GM1 gangliosides exposed on the luminal surface of intestinal epithelial cells. The crystal structure of choleragenoid has been independently solved and refined at 2.4 A resolution by combining single isomorphous replacement with non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence of the A subunit the central cavity of the B pentamer is a highly solvated channel. The binding of choleragenoid to the A subunit or to its receptor pentasaccharide modestly affects the local stereochemistry without perceptibly altering the subunit interface.
About this Structure
1FGB is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.
Reference
The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid., Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG, J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:7658472 Page seeded by OCA on Fri May 2 16:17:34 2008
