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1y7q

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Revision as of 16:49, 20 October 2021

Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain

Structural highlights

1y7q is a 2 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	ZNF174, ZSCAN8 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ZN174_HUMAN] Transcriptional repressor.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Retroviral assembly is driven by multiple interactions mediated by the Gag polyprotein, the main structural component of the forming viral shell. Critical determinants of Gag oligomerization are contained within the C-terminal domain (CTD) of the capsid protein, which also harbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable Gag. An unexpected clue about the MHR function in retroviral assembly emerges from the structure of the zinc finger-associated SCAN domain we describe here. The SCAN dimer adopts a fold almost identical to that of the retroviral capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like element between the monomers. Mutations in retroviral capsid proteins and functional data suggest that a SCAN-like MHR-swapped CTD dimer forms during immature particle assembly. In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance.

Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.,Ivanov D, Stone JR, Maki JL, Collins T, Wagner G Mol Cell. 2005 Jan 7;17(1):137-43. PMID:15629724^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Williams AJ, Khachigian LM, Shows T, Collins T. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. J Biol Chem. 1995 Sep 22;270(38):22143-52. PMID:7673192
↑ Ivanov D, Stone JR, Maki JL, Collins T, Wagner G. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Mol Cell. 2005 Jan 7;17(1):137-43. PMID:15629724 doi:10.1016/j.molcel.2004.12.015

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y7q"

@@ Line 3: / Line 3: @@
 <StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF174, ZSCAN8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [http://pdbe.org/1y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [http://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [https://pdbe.org/1y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [https://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>
+[[https://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN]] Transcriptional repressor.<ref>PMID:7673192</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1y7q

From Proteopedia

Revision as of 16:49, 20 October 2021

Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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