1fh0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1fh0.jpg|left|200px]]
[[Image:1fh0.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1fh0 |SIZE=350|CAPTION= <scene name='initialview01'>1fh0</scene>, resolution 1.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1fh0", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BNS:HYDROSULFONYLBENZENE'>BNS</scene>, <scene name='pdbligand=NFP:3-AMINO-5-PHENYLPENTANE'>NFP</scene>, <scene name='pdbligand=ODS:4-METHYLPIPERAZIN-1-YL+CARBONYL+GROUP'>ODS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1fh0| PDB=1fh0 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fh0 OCA], [http://www.ebi.ac.uk/pdbsum/1fh0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fh0 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR'''
'''CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR'''
Line 26: Line 23:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Somoza, J R.]]
[[Category: Somoza, J R.]]
-
[[Category: cancer]]
+
[[Category: Cancer]]
-
[[Category: cathepsin]]
+
[[Category: Cathepsin]]
-
[[Category: papain]]
+
[[Category: Papain]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:18:52 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:22:44 2008''
+

Revision as of 13:18, 2 May 2008

Image:1fh0.jpg

Template:STRUCTURE 1fh0

CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR


Overview

Cathepsin V is a lysosomal cysteine protease that is expressed in the thymus, testis and corneal epithelium. We have determined the 1.6 A resolution crystal structure of human cathepsin V associated with an irreversible vinyl sulfone inhibitor. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. This study provides a framework for understanding the structural basis for cathepsin V's activity and will aid in the design of inhibitors of this enzyme. A comparison of cathepsin V's active site with the active sites of related proteases revealed a number of differences, especially in the S2 and S3 subsites, that could be exploited in identifying specific cathepsin V inhibitors or in identifying inhibitors of other cysteine proteases that would be selective against cathepsin V.

About this Structure

1FH0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cathepsin V., Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME, Biochemistry. 2000 Oct 17;39(41):12543-51. PMID:11027133 Page seeded by OCA on Fri May 2 16:18:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fh0"
Personal tools