3c76
From Proteopedia
(Difference between revisions)
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<StructureSection load='3c76' size='340' side='right'caption='[[3c76]], [[Resolution|resolution]] 1.07Å' scene=''> | <StructureSection load='3c76' size='340' side='right'caption='[[3c76]], [[Resolution|resolution]] 1.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3c76]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3c76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhopr Rhopr]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2asz 2asz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C76 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene></td></tr> | ||
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2at0|2at0]], [[2at3|2at3]], [[1x8p|1x8p]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2at0|2at0]], [[2at3|2at3]], [[1x8p|1x8p]]</div></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c76 OCA], [https://pdbe.org/3c76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c76 RCSB], [https://www.ebi.ac.uk/pdbsum/3c76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c76 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |
Revision as of 19:07, 20 October 2021
1.07 A crystal structure of L133V mutant of nitrophorin 4 from Rhodnius prolixus complexed with ammonia at PH 7.5
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Categories: Large Structures | Rhopr | Amoia, A M | Montfort, W R | Beta barrel | Ferric heme | Iron | Lipocalin | Metal-binding | Secreted | Transport protein | Vasoactive | Vasodilator