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3cyi

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==Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+==
==Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+==
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<StructureSection load='3cyi' size='340' side='right' caption='[[3cyi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3cyi' size='340' side='right'caption='[[3cyi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CYI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rii|2rii]], [[1xw4|1xw4]], [[1xw3|1xw3]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rii|2rii]], [[1xw4|1xw4]], [[1xw3|1xw3]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRXN1, C20orf139, SRX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRXN1, C20orf139, SRX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfiredoxin Sulfiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.98.2 1.8.98.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sulfiredoxin Sulfiredoxin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.98.2 1.8.98.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyi OCA], [http://pdbe.org/3cyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyi RCSB], [http://www.ebi.ac.uk/pdbsum/3cyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyi OCA], [https://pdbe.org/3cyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cyi RCSB], [https://www.ebi.ac.uk/pdbsum/3cyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
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[[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Sulfiredoxin]]
[[Category: Sulfiredoxin]]
[[Category: Johnson, L C]]
[[Category: Johnson, L C]]

Revision as of 19:16, 20 October 2021

Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+

PDB ID 3cyi

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