1fi0
From Proteopedia
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[[Image:1fi0.gif|left|200px]] | [[Image:1fi0.gif|left|200px]] | ||
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'''SOLUTION STRUCTURE OF HIV-1 VPR (13-33) PEPTIDE IN MICELLS''' | '''SOLUTION STRUCTURE OF HIV-1 VPR (13-33) PEPTIDE IN MICELLS''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FI0 is a [[Single protein]] structure | + | 1FI0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Stangler, T.]] | [[Category: Stangler, T.]] | ||
[[Category: Willbold, D.]] | [[Category: Willbold, D.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:20:51 2008'' | |
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Revision as of 13:20, 2 May 2008
SOLUTION STRUCTURE OF HIV-1 VPR (13-33) PEPTIDE IN MICELLS
Overview
Human immunodeficiency virus type 1 protein R (HIV-1 Vpr) promotes nuclear entry of viral nucleic acids in nondividing cells, causes G2 cell cycle arrest and is involved in cellular differentiation and cell death. Also, Vpr subcellular localization is as variable as its functions. It is known that, consistent with its role in nuclear transport, Vpr localizes to the nuclear envelope of human cells. Further, a reported ion channel activity of Vpr obviously is dependent on its localization in or at membranes. We focused our structural studies on the secondary structure of a peptide consisting of residues 13-33 of HIV-1 Vpr in micelles. Employing nuclear magnetic resonance and circular dichroism spectroscopy we found this part of Vpr, known to be essential for nuclear localization, to be almost completely alpha helical. Our results provide structural data suggesting residues 13-33 of Vpr to form an amphipathic, leucine-zipper-like alpha helix that serves as a basis for interactions with a variety of viral and cellular factors.
About this Structure
1FI0 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Solution structure of human immunodeficiency virus type 1 Vpr(13-33) peptide in micelles., Engler A, Stangler T, Willbold D, Eur J Biochem. 2001 Jan;268(2):389-95. PMID:11168374 Page seeded by OCA on Fri May 2 16:20:51 2008
