2izt
From Proteopedia
(Difference between revisions)
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<StructureSection load='2izt' size='340' side='right'caption='[[2izt]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2izt' size='340' side='right'caption='[[2izt]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2izt]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2izt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=23D:N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE'>23D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23D:N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE'>23D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2chl|2chl]], [[2izr|2izr]], [[2izs|2izs]], [[2izu|2izu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2chl|2chl]], [[2izr|2izr]], [[2izs|2izs]], [[2izu|2izu]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izt OCA], [https://pdbe.org/2izt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izt RCSB], [https://www.ebi.ac.uk/pdbsum/2izt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izt ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN]] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 20:43, 20 October 2021
Structure of casein kinase gamma 3 in complex with inhibitor
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Categories: Human | Large Structures | Non-specific serine/threonine protein kinase | Arrowsmith, C | Bunkoczi, G | Das, S | Debreczeni, J E | Delft, F von | Edwards, A | Fedorov, O | Gileadi, O | Knapp, S | Rellos, P | Salah, E | Savitsky, P | Sundstrom, M | Weigelt, J | Nucleotide-binding | Ransferase | Transferase | Wnt signaling pathway
