Macrophage inhibitory factor

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<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'>
<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'>
== Function ==
== Function ==
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'''Macrophage inhibitory factor''' or '''Macrophage migration inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>.
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'''Macrophage inhibitory factor''' or '''Macrophage migration inhibitory factor''' (MIF) is an inflammatory cytokine. '''MIF2''' or '''D-dopachrome tautomerase''' or '''D-dopachrome decarboxylase''' is a pro-inflammatory cytokine which regulates the innate and adaptive immune response<ref>PMID:22507380</ref>. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>.
== Relevance ==
== Relevance ==

Current revision

Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh)

Drag the structure with the mouse to rotate

References

  1. ↑ Merk M, Mitchell RA, Endres S, Bucala R. D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family. Cytokine. 2012 Jul;59(1):10-7. doi: 10.1016/j.cyto.2012.03.014. Epub 2012 Apr 14. PMID:22507380 doi:http://dx.doi.org/10.1016/j.cyto.2012.03.014
  2. ↑ Nishihira J. Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. J Interferon Cytokine Res. 2000 Sep;20(9):751-62. PMID:11032394 doi:http://dx.doi.org/10.1089/10799900050151012
  3. ↑ Bach JP, Deuster O, Balzer-Geldsetzer M, Meyer B, Dodel R, Bacher M. The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 2009 May 15;115(10):2031-40. doi: 10.1002/cncr.24245. PMID:19326434 doi:http://dx.doi.org/10.1002/cncr.24245
  4. ↑ Shimizu T. Role of macrophage migration inhibitory factor (MIF) in the skin. J Dermatol Sci. 2005 Feb;37(2):65-73. PMID:15659324 doi:http://dx.doi.org/10.1016/j.jdermsci.2004.08.007
  5. ↑ Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med. 2010 Mar;16(3-4):116-21. doi: 10.2119/molmed.2009.00123. Epub 2010 Feb, 28. PMID:20200619 doi:http://dx.doi.org/10.2119/molmed.2009.00123
  6. ↑ Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25. PMID:17526494 doi:http://dx.doi.org/10.1074/jbc.M701825200

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