1fiv

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[[Image:1fiv.gif|left|200px]]
[[Image:1fiv.gif|left|200px]]
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{{Structure
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|PDB= 1fiv |SIZE=350|CAPTION= <scene name='initialview01'>1fiv</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1fiv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NPY:NAPHTHALENE'>NPY</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1fiv| PDB=1fiv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fiv OCA], [http://www.ebi.ac.uk/pdbsum/1fiv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fiv RCSB]</span>
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'''STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS'''
'''STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS'''
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Zdanov, A.]]
[[Category: Zdanov, A.]]
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[[Category: hydrolase (acid proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:22:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:23:47 2008''
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Revision as of 13:22, 2 May 2008

Image:1fiv.gif

Template:STRUCTURE 1fiv

STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS


Overview

The crystal structure of a recombinant form of the proteinase encoded by the feline immunodeficiency virus (FIV PR) has been solved at 2 A resolution and refined to an R-factor of 0.148. The refined structure includes a peptidomimetic, statine-based inhibitor, LP-149, which is an even more potent inhibitor of HIV PR. Kinetic parameters were obtained for the cleavage of five substrates by FIV PR, and inhibition constants were measured for four inhibitors. The structure of FIV PR resembles other related retroviral enzymes although few inhibitors of HIV PR are capable of inhibiting FIV PR. The structure of FIV PR will enhance our knowledge of this class of enzymes, and will direct testing of new proteinase inhibitors in a feline animal model.

About this Structure

1FIV is a Single protein structure of sequence from Feline immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus., Wlodawer A, Gustchina A, Reshetnikova L, Lubkowski J, Zdanov A, Hui KY, Angleton EL, Farmerie WG, Goodenow MM, Bhatt D, et al., Nat Struct Biol. 1995 Jun;2(6):480-8. PMID:7664111 Page seeded by OCA on Fri May 2 16:22:39 2008

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