1fjm

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[[Image:1fjm.gif|left|200px]]
[[Image:1fjm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fjm |SIZE=350|CAPTION= <scene name='initialview01'>1fjm</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1fjm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACB:3-METHYL-ASPARTIC+ACID'>ACB</scene>, <scene name='pdbligand=ADD:2,6,8-TRIMETHYL-3-AMINO-9-BENZYL-9-METHOXYNONANOIC+ACID'>ADD</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAB:4-CARBOXY-4-AMINOBUTANAL'>CAB</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fjm| PDB=1fjm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fjm OCA], [http://www.ebi.ac.uk/pdbsum/1fjm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fjm RCSB]</span>
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}}
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'''PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN'''
'''PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Nairn, A C.]]
[[Category: Nairn, A C.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: toxin]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:24:10 2008''
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Revision as of 13:24, 2 May 2008

Image:1fjm.gif

Template:STRUCTURE 1fjm

PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN


Overview

The crystal structure of mammalian protein phosphatase-1, complexed with the toxin microcystin and determined at 2.1 A resolution, reveals that it is a metalloenzyme unrelated in architecture to the tyrosine phosphatases. Two metal ions are positioned by a central beta-alpha-beta-alpha-beta scaffold at the active site, from which emanate three surface grooves that are potential binding sites for substrates and inhibitors. The carboxy terminus is positioned at the end of one of the grooves such that regulatory sequences following the domain might modulate function. The fold of the catalytic domain is expected to be closely preserved in protein phosphatases 2A and 2B (calcineurin).

About this Structure

1FJM is a Single protein structure of sequence from Microcystis aeruginosa and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1., Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, Kuriyan J, Nature. 1995 Aug 31;376(6543):745-53. PMID:7651533 Page seeded by OCA on Fri May 2 16:24:20 2008

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OCA

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