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1fkn

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[[Image:1fkn.gif|left|200px]]
[[Image:1fkn.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1fkn", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ALQ:2-METHYL-PROPIONIC+ACID'>ALQ</scene>, <scene name='pdbligand=LOL:LEUCINOL'>LOL</scene>
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{{STRUCTURE_1fkn| PDB=1fkn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkn OCA], [http://www.ebi.ac.uk/pdbsum/1fkn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fkn RCSB]</span>
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'''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''
'''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''
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[[Category: Wu, S.]]
[[Category: Wu, S.]]
[[Category: Zhang, X C.]]
[[Category: Zhang, X C.]]
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[[Category: alzheimer's disease]]
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[[Category: Alzheimer's disease]]
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[[Category: aspartic protease]]
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[[Category: Aspartic protease]]
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[[Category: base]]
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[[Category: Base]]
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[[Category: beta-secretase]]
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[[Category: Beta-secretase]]
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[[Category: memapsin 2]]
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[[Category: Memapsin 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:26:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:24:45 2008''
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Revision as of 13:26, 2 May 2008

Image:1fkn.gif


PDB ID 1fkn

Drag the structure with the mouse to rotate
1fkn, resolution 1.90Å ()
Non-Standard Residues:
Activity: Memapsin 2, with EC number 3.4.23.46
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR


Overview

Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.

About this Structure

1FKN is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1FKN with [Amyloid-beta Precursor Protein]. Full crystallographic information is available from OCA.

Reference

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor., Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J, Science. 2000 Oct 6;290(5489):150-3. PMID:11021803 Page seeded by OCA on Fri May 2 16:26:16 2008

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OCA

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