1fl8

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[[Image:1fl8.gif|left|200px]]
[[Image:1fl8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fl8 |SIZE=350|CAPTION= <scene name='initialview01'>1fl8</scene>
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The line below this paragraph, containing "STRUCTURE_1fl8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5&#39;-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=T6A:N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5&#39;-MONOPHOSPHATE'>T6A</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=U8U:5-METHYLAMINOMETHYL-2-THIOURIDINE-5&#39;-MONOPHOSPHATE'>U8U</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fl8| PDB=1fl8 | SCENE= }}
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|RELATEDENTRY=[[1bzu|1BZU]], [[1bz2|1BZ2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fl8 OCA], [http://www.ebi.ac.uk/pdbsum/1fl8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fl8 RCSB]</span>
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}}
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'''HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE'''
'''HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE'''
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==About this Structure==
==About this Structure==
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1FL8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL8 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL8 OCA].
==Reference==
==Reference==
Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure., Sundaram M, Durant PC, Davis DR, Biochemistry. 2000 Oct 17;39(41):12575-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11027137 11027137]
Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure., Sundaram M, Durant PC, Davis DR, Biochemistry. 2000 Oct 17;39(41):12575-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11027137 11027137]
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[[Category: Protein complex]]
 
[[Category: Davis, D R.]]
[[Category: Davis, D R.]]
[[Category: Durant, P C.]]
[[Category: Durant, P C.]]
[[Category: Sundaram, M.]]
[[Category: Sundaram, M.]]
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[[Category: anticodon]]
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[[Category: Anticodon]]
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[[Category: mnm5s2u]]
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[[Category: Mnm5s2u]]
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[[Category: pseudouridine]]
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[[Category: Pseudouridine]]
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[[Category: t6a]]
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[[Category: T6a]]
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[[Category: trna]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:27:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:07 2008''
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Revision as of 13:27, 2 May 2008

Image:1fl8.gif

Template:STRUCTURE 1fl8

HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE


Overview

Modified nucleosides in the anticodon domain of Escherichia coli tRNA(Lys) are necessary for high-affinity codon recognition and reading frame maintenance. Human tRNA(Lys,3) is the specific primer for HIV-1 reverse transcriptase and also requires nucleoside modification for proper function. We now present NMR solution structures for the fully modified 17-nucleotide E. coli tRNA(Lys) anticodon stem-loop domain (ASL). NMR data were also collected for several partially modified ASLs, revealing the contributions each modified nucleoside (mnm(5)s(2)U34, t(6)A37, and psi39) makes in transforming the disordered, unmodified tRNA ASL into the highly ordered native structure. The solution structure of the native ASL domain provides insight into longstanding questions regarding both wobble position modification and the nearly ubiquitous t(6)A37 found in tRNAs with an adjacent U at position 36. Native tRNA(Lys) has a U-turn structure similar to the yeast tRNA(Phe) crystal structure, unlike previously proposed "unconventional" anticodon structures characterized by stable interactions between mnm(5)s(2)U-34 and t(6)A-37.

About this Structure

Full crystallographic information is available from OCA.

Reference

Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure., Sundaram M, Durant PC, Davis DR, Biochemistry. 2000 Oct 17;39(41):12575-84. PMID:11027137 Page seeded by OCA on Fri May 2 16:27:31 2008

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