1fli

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[[Image:1fli.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1fli", creates the "Structure Box" on the page.
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|GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1fli| PDB=1fli | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fli OCA], [http://www.ebi.ac.uk/pdbsum/1fli PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fli RCSB]</span>
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'''DNA-BINDING DOMAIN OF FLI-1'''
'''DNA-BINDING DOMAIN OF FLI-1'''
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[[Category: Thompson, C B.]]
[[Category: Thompson, C B.]]
[[Category: Yu, L.]]
[[Category: Yu, L.]]
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[[Category: transcription/dna]]
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[[Category: Transcription/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:28:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:15 2008''
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Revision as of 13:28, 2 May 2008

Image:1fli.gif

Template:STRUCTURE 1fli

DNA-BINDING DOMAIN OF FLI-1


Overview

Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA.

About this Structure

1FLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:7773776 Page seeded by OCA on Fri May 2 16:28:02 2008

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