This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7c5i
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of C150A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with PO4 at 2.49 Angstrom resolution== | ==Crystal Structure of C150A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with PO4 at 2.49 Angstrom resolution== | ||
| - | <StructureSection load='7c5i' size='340' side='right'caption='[[7c5i]]' scene=''> | + | <StructureSection load='7c5i' size='340' side='right'caption='[[7c5i]], [[Resolution|resolution]] 2.48Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C5I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7c5i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C5I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c5i OCA], [https://pdbe.org/7c5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c5i RCSB], [https://www.ebi.ac.uk/pdbsum/7c5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c5i ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECBD_2224 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=469008 ECOBD])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c5i OCA], [https://pdbe.org/7c5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c5i RCSB], [https://www.ebi.ac.uk/pdbsum/7c5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c5i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/A0A140NCK4_ECOBD A0A140NCK4_ECOBD]] Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.[ARBA:ARBA00003501] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ecobd]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bao | + | [[Category: Bao, L Y]] |
| - | [[Category: Bostrom | + | [[Category: Bostrom, I K]] |
| - | [[Category: Chen | + | [[Category: Chen, A Q]] |
| - | [[Category: Gu | + | [[Category: Gu, S H]] |
| - | [[Category: Ji | + | [[Category: Ji, C N]] |
| - | [[Category: Li | + | [[Category: Li, J X]] |
| - | [[Category: Liu | + | [[Category: Liu, M R]] |
| - | [[Category: Wang | + | [[Category: Wang, Y D]] |
| - | [[Category: Yao | + | [[Category: Yao, Y C]] |
| - | [[Category: Zhang L]] | + | [[Category: Zhang, L]] |
| + | [[Category: Ecgapdh 1]] | ||
| + | [[Category: Nad]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 15:56, 3 November 2021
Crystal Structure of C150A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with PO4 at 2.49 Angstrom resolution
| |||||||||||
Categories: Ecobd | Large Structures | Bao, L Y | Bostrom, I K | Chen, A Q | Gu, S H | Ji, C N | Li, J X | Liu, M R | Wang, Y D | Yao, Y C | Zhang, L | Ecgapdh 1 | Nad | Oxidoreductase
