1xqr

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<StructureSection load='1xqr' size='340' side='right'caption='[[1xqr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1xqr' size='340' side='right'caption='[[1xqr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQR FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xqs|1xqs]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xqs|1xqs]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqr OCA], [http://pdbe.org/1xqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqr RCSB], [http://www.ebi.ac.uk/pdbsum/1xqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqr OCA], [https://pdbe.org/1xqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqr RCSB], [https://www.ebi.ac.uk/pdbsum/1xqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HPBP1_HUMAN HPBP1_HUMAN]] Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.<ref>PMID:9830037</ref> <ref>PMID:10786638</ref> <ref>PMID:12651857</ref> <ref>PMID:15215316</ref>
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[[https://www.uniprot.org/uniprot/HPBP1_HUMAN HPBP1_HUMAN]] Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.<ref>PMID:9830037</ref> <ref>PMID:10786638</ref> <ref>PMID:12651857</ref> <ref>PMID:15215316</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 16:18, 3 November 2021

Crystal structure of the HspBP1 core domain

PDB ID 1xqr

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