1xta

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<StructureSection load='1xta' size='340' side='right'caption='[[1xta]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='1xta' size='340' side='right'caption='[[1xta]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XTA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XTA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xta OCA], [http://pdbe.org/1xta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xta RCSB], [http://www.ebi.ac.uk/pdbsum/1xta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xta ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xta OCA], [https://pdbe.org/1xta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xta RCSB], [https://www.ebi.ac.uk/pdbsum/1xta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xta ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>
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[[https://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 16:19, 3 November 2021

Crystal Structure of Natrin, a snake venom CRISP from Taiwan cobra (Naja atra)

PDB ID 1xta

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